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ОВЁС В ЛЕЧЕНИИ ОЖИРЕНИЯ И МЕТАБОЛИЧЕСКОГО СИНДРОМА

Вестник фундаментальной и клинической медицины , 2024, № 5 (11)

Тема статьи

ОВЁС В ЛЕЧЕНИИ ОЖИРЕНИЯ И МЕТАБОЛИЧЕСКОГО СИНДРОМА (97-112)
Авторы

Г.Х. Ражабова, К.Ш. Джумаев, Н.С. Нурова

Учреждение

Бухарский государственный медицинский институт

Аннотация

Проведённые многочисленные эпидемиологические исследования показали, что МС в целом встречается приблизительно у 25% населения Земли, и имеет тенденцию к увели-чению и омоложению, является одной из основных проблем современной медицины и пятой по значимости причиной смерти в мире. Среди известных этиологических факторов МС основ-ные место занимают распространённые явления современности – такие как нерациональное питание, популярность пищи «быстрого питания» - фастфуда, приём генетически модифи-цированных продуктов, пищи, с повышенным количеством углеводов и животных жиров и как следствие этого нарушение микробиома кишечника. В статье представлен обзор научных данных, опубликованных в источниках MEDLINE, PubMed, E-library, scholar.google.ru. за пери-од с 2016 года по 2023 года. Производился поиск, по ключевым словам, «овёс», «метаболиче-ский синдром», «Avena sativa L.», «β- глюкан», «пробиотики и ожирение». Выбраны статьи - мета анализы, систематические обзоры, рандомизированные, плацебо контролируемые кли-нические исследования. Исключены из поиска статьи с недостаточной доказательной базой. Всего представлено 103 статей. Овёс имеет интересный профиль питания, который включает высококачественный бе-лок, ненасыщенные жиры, растворимое волокно, полифенольные соединения и питательные микроэлементы. Проведённые рандомизированные, контролируемые исследования на разных частях света, систематические обзоры и мета анализы показали, что приём овса, благодаря богатому химическому составу, наличию пробиотика - β- глюкана оказывает гипогликемиче-ское, гиполипидемическое, антиоксидантное, гипотензивное, противовоспалительное воздей-ствие. Эти свойства, в свою очередь нормализуют микробиом кишечника. Эти свойства зёрен овса полезны не только для профилактики, но и терапии компонентов метаболического син-дрома- ожирения, дисслипидемии, сахарного диабета, инсулинрезистентности, и метаболи-ческого синдрома в целом. Продукты переработки овса нужно шире внедрять в пищевой ра-цион как здоровых, в целях профилактики, так и больных метаболическим синдромом, для ле-чения и предупреждения осложнений.

Ключевые слова

гипергликемия, метаболический синдром, ожирение, овёс, β-глюкан, ре-зистентности к инсулину.

Литературы

  1. Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO Consultation. World Health Organization: Geneva, Switzerland; 1999. [Last accessed on 2020 Oct 10]. Available from: https://apps.who.int/iris/bitstream/handle/10665/66040/WHO_NCD_ NCS_99.2.pdf.
  2. Урясьев ОМ, Горбунова ДЮ, Щербакова ОН, Пыко АА. Метаболический синдром-нерешённая проблема медицины и современного общества. Вестник Смоленской государственной медицинской академии. 2017, Т. 16, 1, 160-164.
  3. Абдуллозода СМ. Некоторые аспекты эпидемиологии и этиопатогенеза метаболического синдрома. Вестник Авиценны. 2020, Т. 22, № 4, 580-594. – https://doi.org/10.25005/2074-0581-2020-22-4-580-594.
  4. Кытикова ОЮ, Антонюк МВ, Кантур ТА, Новгородцева ТП, Денисенко ЮК. Распространённость и биомаркеры метаболического синдрома. Ожирение и метаболизм. 2021, Т. 18, №. 3, 302-312.
  5. Safaei M, Sundararajan, EA, Driss M, Boulila W, Shapi'i A. A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine-learning approaches used to predict obesity. Computers in biology and medicine. 2021, Т. 136, 104754.
  6. Global status report on non-communicable diseases 2014. Geneva, Switzer-land: WHO; 2015. 282 p.
  7. Mozaffarian D, Fahimi S, Singh GM, Micha R, Khatibzadeh S, Engell RE, Lim S, et al. Global burden of diseases nutrition and chronic diseases expert group. Global sodium consumption and death from cardiovascular causes. N Engl J Med. 2014; 371(7): 624-34. Available from: https://doi.org/10.1056/NEJMoa1304127.
  8. Newman NK, Zhang Y, Padiadpu J, Mi-randa CL, Magana AA, Wong CP, Hioki KA, Pederson JW, Li Z, Gurung M, Bruce AM, Brown K, Bobe G, Sharpton TJ, Shulzhenko N, Maier CS, Stevens JF, Gombart AF, Morgun A. Reducing gut microbiome-driven adipose tissue inflammation alleviates metabolic syndrome. Microbiome. 2023 Sep 21;11(1):208 https://doi.org/10.1186/s40168-023-01637-4.
  9. Бобунов ДН, Иорданишвили АК, Михайлов ВД, Шапурко ОН. Роль микробиоты кишечника в реабилитации больных с ожирением. Экспериментальная и клиническая гастроэнтерология. 2019, № 5(165), 105-110. – https://doi.org/10.31146/1682-8658-ecg-165-5-105-110.
  10. Ji J, Jin W, Liu SJ, Jiao Z, Li X. Probi-otics, prebiotics, and postbiotics in health and disease. MedComm (2020). 2023 Nov 4;4(6):e420. doi: 10.1002/mco2.420.
  11. Park S, Zhang T, Kang S. Fecal Micro-biota Composition, Their Interactions, and Met-agenome Function in US Adults with Type 2 Diabetes According to Enterotypes. Int J Mol Sci. 2023 May 31;24(11):9533. https://doi.org/10.3390/ijms24119533.
  12. Sidhu M, van der Poorten D. The gut microbiome. Aust Fam Physician. 2017; 46(4): 206-11.
  13. Goutzourelas N, Orfanou M, Charizanis I, Leon G, Spandidos DA, Kouretas D. GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy. Exp Ther Med. 2018 Aug;16(2):635-642. https://doi.org/10.3892/etm.2018.6204.
  14. Кароматов ИД, Шодиева МС. Овёс как лечебное растение. Биология и интегративная медицина 2018, №9 (26), 165.
  15. Blaak EE, Goossens GH. Metabolic phenotyping in people living with obesity: Implications for dietary prevention. Rev Endocr Metab Disord. 2023 Oct; 24(5):825-838. https://doi.org/10.1007/s11154-023-09830-4.
  16. Boffetta P, Thies F, Kris-Etherton P. Epidemiological studies of oats consumption and risk of cancer and overall mortality. Br J Nutr. 2014, Oct., 112 Suppl 2, S14-8. https://doi.org/10.1017/S0007114514002268.
  17. Кароматов ИД. Фитотерапия – руководство для врачей, том 2 Бухара «Дурдона» 2022, 1024 с.
  18. Food and Agriculture Organization of the United Nations https://www.fao.org/home/en/].
  19. Ihsan M, Nisar M, Nazir N, Zahoor M, Khalil AAK, Ghafoor A, et al. Genetic diversity in nutritional composition of oat (Avena sativa L.) germplasm reported from Pakistan. Saudi J Biol Sci. The Author(s). 2022; 29:1487–500.
  20. Каширских ЕВ, Бабич ОО, Асякина ЛК, Носкова СЮ. Изучение состава и физико-химических свойств зёрен овса посевного. Вестник современных исследований. 2017, № 10-1(13), 14-19.
  21. Варгач ЮИ, Хорева ВИ, Лоскутов ИГ. Содержание белка, масла и крахмала в зерновках голозерных и пленчатых форм овса. Плодоводство и ягодоводство России. 2017, Т. 51, 67-71.
  22. Paudel D, Dhungana B, Caffe M, Krishnan P. A review of health-beneficial properties of oats. Foods. 2021; 10:1–23. https://doi.org/10.3390/foods10112591.
  23. Yang J, Wang P, Wu W, Zhao Y, Idehen E, Sang S. Steroidal Saponins in Oat Bran. J Agric Food Chem. 2016, Feb 24, 64(7), 1549-1556. https://doi.org/10.1021/acs.jafc.5b06071.
  24. Hou Y, Peng S, Song Z, Bai F, Li X, Fang J. Oat polyphenol avenanthramide-2c confers protection from oxidative stress by regulating the Nrf2-ARE signaling pathway in PC12 cells. Arch Biochem Biophys. 2021 Jul 30; 706: 108857. https://doi.org/10.1016/j.abb.2021.108857.
  25. Alemayehu GF, Forsido SF, Tola YB, Amare E. Nutritional and Phytochemical Composition and Associated Health Benefits of Oat (Avena sativa) Grains and Oat-Based Fermented Food Products. Scientific World Journal. 2023 Jul 17; 2023: 2730175. https://doi.org/10.1155/2023/2730175.
  26. Юлдашева НК, Гусакова СД, Нуруллаева ДХ и др. Нейтральные липиды плодов овса посевного (Avena sativa L.). Разработка и регистрация лекарственных средств. 2020, Т. 9, № 4, 40-43. https://doi.org/10.33380/2305-2066-2020-9-4-40-43.
  27. Баталова ГА, Попов ВС, Сергеева СС, Красильников ВН. Жирно-кислотный состав липидов зерна голозерного овса отечественной селекции. Российская сельскохозяйственная наука. 2018, № 4, 13-15. – https://doi.org/ 10.31857/S250026270000549-8.
  28. Punia S, Sandhu KS, Dhull SB, Siroha AK, Purewal SS, Kaur M, Kidwai MK. Oat starch: Physico-chemical, morphological, rheological characteristics and its applications - A review. Int J Biol Macromol. 2020 Jul 1; 154: 493-498. https://doi.org/10.1016/j.ijbiomac.2020.03.083.
  29. Белкина РИ. О пищевой ценности зерна овса и продуктов его переработки. Агропродовольственная политика России. 2022, № 1. – С. 2-5.
  30. Musa-Veloso K, Fallah S, O'Shea M, Chu Y. Assessment of Intakes and Patterns of Cooked Oatmeal Consumption in the U.S. Using Data from the National Health and Nutrition Examination Surveys. Nutrients. 2016, Aug 17, 8(8). pii: E503. https://doi.org/10.3390/nu8080503.
  31. Fulgoni VL, 3rd, Chu Y, O'Shea M, Slavin JL, DiRienzo MA. Oatmeal consumption is associated with better diet quality and lower body mass index in adults: the National Health and Nutrition Examination Survey (NHANES), 2001-2010. Nutr Res. 2015, Dec., 35(12), 1052-1059. https://doi.org/10.1016/j.nutres.2015.09.015).
  32. Geliebter A, Grillot CL, Aviram-Friedman R, Haq S, Yahav E, Hashim SA. Effects of oatmeal and corn flakes cereal break-fasts on satiety, gastric emptying, glucose, and appetite-related hormones. Ann Nutr Metab. 2015, 66(2-3), 93-103. https://doi.org/10.1159/000365933.
  33. Johnsen NF, Frederiksen K, Christensen J, Skeie G, Lund E, Landberg R, Johansson I, Nilsson LM, Halkjær J, Olsen A, Overvad K, Tjønneland A. Whole-grain products and whole-grain types are associated with lower all-cause and cause-specific mortality in the Scandinavian HELGA cohort. Br J Nutr. 2015, Aug 28, 114(4), 608-623. https://doi.org/10.1017/S0007114515001701.
  34. Hossain MM, Tovar J, Cloetens L, Florido MTS, Petersson K, Prothon F, Nilsson A. Oat Polar Lipids Improve Cardiometabolic-Related Markers after Breakfast and a Subsequent Standardized Lunch: A Randomized Crossover Study in Healthy Young Adults. Nutrients. 2021 Mar 18; 13(3): 988. https://doi.org/10.3390/nu13030988.
  35. Oh KK, Yoon SJ, Lee SB, Lee SY, Gupta H, Ganesan R, Sharma SP, Won SM, Jeong JJ, Kim DJ, Suk KT. The convergent ap-plication of metabolites from Avena sativa and gut microbiota to ameliorate non-alcoholic fatty liver disease: a network pharmacology study. J Transl Med. 2023 Apr 17; 21(1): 263. https://doi.org/10.1186/s12967-023-04122-6.
  36. Dioum EHM, Schneider KL, Vigerust DJ, Cox BD, Chu Y, Zachwieja JJ, Furman D. Oats Lower Age-Related Systemic Chronic Inflammation (iAge) in Adults at Risk for Cardiovascular Disease. Nutrients. 2022 Oct 25; 14(21): 4471. https://doi.org/10.3390/nu14214471.
  37. Wong RH, Howe PR, Coates AM, Buckley JD, Berry NM. Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults. J Hypertens. 2013, Jan., 31(1), 192-200. https://doi.org/10.1097/HJH.0b013e32835b04d4/
  38. Singh R, De S, Belkheir A. Avena sativa (Oat), A Potential Neutraceutical and Therapeutic Agent: An Overview. Crit Rev Food Sci Nutr. 2013, 53(2), 126-144.
  39. Munkh-Erdene B, Tsevegsuren N, Davaakhuu G. Study on biochemical and phytochemical composition of oats (Avena Sativa). Вестник Бурятского Государственного Университета Выпуск медицина, фармация, 2015, 12, 11-12.
  40. Yu G, Wang F, Zhang B, Fan J. In vitro inhibition of platelet aggregation by peptides derived from oat (Avena sativa L.), highland barley (Hordeum vulgare Linn. var. nudum Hook. f.), and buckwheat (Fagopyrum esculen-tum Moench) proteins. Food Chem. 2016, Mar 1, 194, 577-586. https://doi.org/10.1016/j.foodchem.2015.08.058.
  41. Bouchard J, Valookaran AF, Aloud BM, Raj P, Malunga LN, Thandapilly SJ, Netticadan T. Impact of oats in the prevention/management of hypertension. Food Chem. 2022 Jul 1; 381: 132198. https://doi.org/10.1016/j.foodchem.2022.132198.
  42. Xi H, Zhou W, Niu Y, Zhu R, Wang S, Guo Y, Liu W, Xiong X, Guo L. Effect of Oat Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Con-trolled Trials. J. Acad. Nutr. Diet. 2023 May; 123(5): 809-823. https://doi.org/10.1016/j.jand.2022.11.010.
  43. Ju Y, Zhang C, Zhang Z, Zhu H, Liu Y, Liu T, Ojo O, Qiu J, Wang X. Effect of Dietary Fiber (Oat Bran) Supplement in Heart Rate Lowering in Patients with Hypertension: A Randomized DASH-Diet-Controlled Clinical Trial. Nutrients. 2022 Jul 30; 14(15): 3148. https://doi.org/10.3390/nu14153148.
  44. Xue Y, Cui L, Qi J, Ojo O, Du X, Liu Y, Wang X. The effect of dietary fiber (oat bran) supplement on blood pressure in patients with essential hypertension: A randomized controlled trial. Nutr Metab Cardiovasc Dis. 2021 Jul 22; 31(8): 2458-2470. https://doi.org/10.1016/j.numecd.2021.04.013.
  45. Zheng Y, Wang X, Zhuang Y, Li Y, Shi P, Tian H, Li X, Chen X. Isolation of novel ACE-inhibitory peptide from naked oat globulin hydrolysates in silico approach: Molecular docking, in vivo antihypertension and effects on renin and intracellular endothelin-1. J Food Sci. 2020 Apr; 85(4): 1328-1337. https://doi.org/10.1111/1750-3841.15115.
  46. Bleakley S, Hayes M, O' Shea N, Gallagher E, Lafarga T. Predicted Release and Analysis of Novel ACE-I, Renin, and DPP-IV Inhibitory Peptides from Common Oat (Avena sativa) Protein Hydrolysates Using in Silico Analysis. Foods. 2017 Dec 4; 6(12): 108. https://doi.org/10.3390/foods6120108.
  47. Darewicz M, Pliszka M, Borawska-Dziadkiewicz J, Minkiewicz P, Iwaniak A. Multi-Bioactivity of Protein Digests and Peptides from Oat (Avena sativa L.) Kernels in the Prevention of the Cardiometabolic Syndrome. Molecules. 2022 Nov 15; 27(22): 7907. https://doi.org/10.3390/molecules27227907.
  48. Mathews R, Kamil A, Chu Y. Global review of heart health claims for oat beta-glucan products. Nutr Rev. 2020 Aug 1; 78(Suppl 1): 78-97. https://doi.org/10.1093/nutrit/nuz069.
  49. Oliveira ECD, Barbosa GC, Corrente JE, Komuro JE, Papini SJ. Oat bran in cardio-vascular risk control in mental disorder. Rev Bras Enferm. 2020; 73 Suppl 1: e20190277. Portuguese, English. https://doi.org/10.1590/0034-7167-2019-0277.
  50. Thomas M, Kim S, Guo W, Collins FW, Wise ML, Meydani M. High Levels of Avenanthramides in Oat-Based Diet Further Sup-press High Fat Diet-Induced Atherosclerosis in Ldlr-/- Mice. J Agric Food Chem. 2018 Jan 17; 66(2): 498-504. https://doi.org/10.1021/acs.jafc.7b04860.
  51. Wang JB, Liu XR, Liu SQ, Mao RX, Hou C, Zhu N, Liu R, Ma HJ, Li Y. Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced Diabetic Rats. Molecules. 2019 Feb 3; 24(3): 558. https://doi.org/10.3390/molecules24030558.
  52. Storz MA, Iraci F. Short-Term Dietary Oatmeal Interventions in Adults With Type 2 Diabetes: A Forgotten Tool. Can J Diabetes. 2020 Jun; 44(4): 301-303. https://doi.org/10.1016/j.jcjd.2019.08.020.
  53. Yin XQ, Zhang XX, Wen J, Liu SQ, Liu XR, Zhou RY, Wang JB. [Effects of the composite of buckwheat-oat-pea on blood glucose in diabetic rats]. Beijing Da Xue Xue Bao Yi Xue Ban. 2021 Jun 18; 53(3): 447-452. Chi-nese. https://doi.org/10.19723/j.issn.1671-167X.2021.03.002.
  54. Li X, Cai X, Ma X, Jing L, Gu J, Bao L, Li J, Xu M, Zhang Z, Li Y. Short- and Long-Term Effects of Wholegrain Oat Intake on Weight Management and Glucolipid Metabolism in Overweight Type-2 Diabetics: A Randomized Control Trial. Nutrients. 2016 Sep 7;8(9):549. https://doi.org/10.3390/nu8090549.
  55. Bao L, Cai X, Xu M, Li Y. Effect of oat intake on glycaemic control and insulin sensitivity: a meta-analysis of randomised con-trolled trials. Br J Nutr. 2014, Aug 14, 112(3), 457-466. https://doi.org/10.1017/S0007114514000889.
  56. Hou Q, Li Y, Li L, Cheng G, Sun X, Li S, Tian H. The Metabolic Effects of Oats Intake in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Nutrients. 2015, Dec 10, 7(12), 10369-10387. https://doi.org/10.3390/nu7125536.
  57. Bozbulut R, Şanlıer N, Döğer E, Bideci A, Çamurdan O, Cinaz P. The effect of beta-glucan supplementation on glycemic control and variability in adolescents with type 1 diabetes mellitus. Diabetes Res Clin Pract. 2020 Nov; 169: 108464. https://doi.org/10.1016/j.diabres.2020.108464.
  58. Zhao M, Zhang H, Wang J, Shan D, Xu Q. Serum metabolomics analysis of the intervention effect of whole grain oats on insulin resistance induced by high-fat diet in rats. Food Res Int. 2020 Sep; 135: 109297. https://doi.org/10.1016/j.foodres.2020.109297.
  59. Steinert RE, Raederstorff D, Wolever TM. Effect of Consuming Oat Bran Mixed in Water before a Meal on Glycemic Responses in Healthy Humans-A Pilot Study. Nutrients. 2016, Aug 26, 8(9). pii: E524. https://doi.org/10.3390/nu8090524.
  60. Guo H, Wu H, Kong X, Zhang N, Li H, Dong X, Li Z. Oat β-glucan ameliorates diabetes in high fat diet and streptozotocin-induced mice by regulating metabolites. J Nutr Biochem. 2023 Mar; 113: 109251. https://doi.org/10.1016/j.jnutbio.2022.109251.
  61. Chen C, Li T, Chen Z, Wang L, Luo X. Absorption Rates and Mechanisms of Avenanthramides in a Caco-2 Cell Model and Their Antioxidant Activity during Absorption. J Agric Food Chem. 2020 Feb 26; 68(8): 2347-2356. https://doi.org/10.1021/acs.jafc.9b06576.
  62. Zhouyao H, Malunga LN, Chu YF, Eck P, Ames N, Thandapilly SJ. The inhibition of intestinal glucose absorption by oat-derived avenanthramides. J Food Biochem. 2022 Oct; 46(10): e14324. https://doi.org/10.1111/jfbc.14324.
  63. Storz MA, Küster O. Hypocaloric, plant-based oatmeal interventions in the treatment of poorly-controlled type 2 diabetes: A re-view. Nutr Health. 2019 Dec; 25(4): 281-290. https://doi.org/10.1177/0260106019874683.
  64. Barati Z, Iravani M, Karandish M, Haghighizadeh MH, Masihi S. The effect of oat bran consumption on gestational diabetes: a randomized controlled clinical trial. BMC Endocr Disord. 2021 Apr 13; 21(1): 67. https://doi.org/10.1186/s12902-021-00731-8.
  65. Zaremba SMM, Gow IF, Drummond S, McCluskey JT, Steinert RE. Effects of oat β-glucan consumption at breakfast on ad libitum eating, appetite, glycemia, insulinemia and GLP-1 concentrations in healthy subjects. Appetite. 2018 Sep 1; 128: 197-204. https://doi.org/10.1016/j.appet.2018.06.019.
  66. Cheng WY, Lam KL, Li X, Kong AP, Cheung PC. Circadian disruption-induced metabolic syndrome in mice is ameliorated by oat β-glucan mediated by gut microbiota. Carbohydr Polym. 2021 Sep 1; 267: 118216. https://doi.org/10.1016/j.carbpol.2021.118216.
  67. Delgado GE, Krämer BK, Scharnagl H, Fauler G, Stojakovic T, März W, Kleber ME, Lammert A. Bile Acids in Patients with Uncontrolled Type 2 Diabetes Mellitus - The Effect of Two Days of Oatmeal Treatment. Exp Clin Endocrinol Diabetes. 2020 Sep; 128(9): 624-630. https://doi.org/10.1055/a-1069-7330.
  68. He LX, Zhao J, Huang YS, Li Y. The difference between oats and beta-glucan extract intake in the management of HbA1c, fasting glucose and insulin sensitivity: a meta-analysis of randomized controlled trials. Food Funct. 2016, Mar, 7(3), 1413-1428. https://doi.org/10.1039/c5fo01364j.
  69. Wehrli F, Taneri PE, Bano A, Bally L, Blekkenhorst LC, Bussler W, Metzger B, Minder B, Glisic M, Muka T, Kern H. Oat Intake and Risk of Type 2 Diabetes, Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis. Nutrients. 2021 Jul 26; 13(8): 2560. https://doi.org/10.3390/nu13082560.
  70. Guo L, Tong LT, Liu L, Zhong K, Qiu J, Zhou S. The cholesterol-lowering effects of oat varieties based on their difference in the composition of proteins and lipids. Lipids Health Dis. 2014, Dec 5, 13, 182. https://doi.org/10.1186/1476-511X-13-182.
  71. Zhou X, Lin W, Tong L, Liu X, Zhong K, Liu L, Wang L, Zhou S. Hypolipidaemic effects of oat flakes and β-glucans derived from four Chinese naked oat (Avena nuda) cultivars in Wistar-Lewis rats. J Sci Food Agric. 2016, Jan 30, 96(2), 644-649. https://doi.org/10.1002/jsfa.7135.
  72. Cui Y, Han X, Hu X, Li T, Li S. Dis-tinctions in structure, rheology, antioxidation, and α-glucosidase inhibitory activity of β-glucans from different species. Int J Biol Macromol. 2023 Oct 25:127684. https://doi.org/10.1016/j.ijbiomac.2023.127684
  73. Wang Q, Ellis PR. Oat β-glucan: physicochemical characteristics in relation to its blood-glucose and cholesterol-lowering proper-ties. Br J Nutr. 2014, Oct., 112 Suppl 2, S4-S13. https://doi.org/10.1017/S0007114514002256.
  74. Schuster J, Benincá G, Vitorazzi R, Morelo Dal Bosco S. Effects of oats on lipid profile, insulin resistance and weight loss. Nutr Hosp. 2015, Nov 1, 32(5), 2111-2116. https://doi.org/10.3305/nh.2015.32.5.9590.
  75. Grundy MM, Fardet A, Tosh SM, Rich GT, Wilde PJ. Processing of oat: the impact on oat's cholesterol lowering effect. Food Funct. 2018 Mar 1; 9(3): 1328-1343. https://doi.org/10.1039/c7fo02006f.
  76. de Morais Junior AC, Schincaglia RM, Viana RB, Armet AM, Prado CM, Walter J, Mota JF. The separate effects of whole oats and isolated beta-glucan on lipid profile: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2023 Feb; 53: 224-237. https://doi.org/10.1016/j.clnesp.2022.12.019.
  77. Yu S, Wang J, Li Y, Wang X, Ren F, Wang X. Structural Studies of Water-Insoluble β-Glucan from Oat Bran and Its Effect on Improving Lipid Metabolism in Mice Fed High-Fat Diet. Nutrients. 2021 Sep 18; 13(9): 3254. https://doi.org/10.3390/nu13093254.
  78. Xu D, Wang S, Feng M, Shete V, Chu Y, Kamil A, Yang C, Liu H, Xia H, Wang X, Sun G, Yang Y. Serum Metabolomics Reveals Underlying Mechanisms of Cholesterol-Lowering Effects of Oat Consumption: A Randomized Controlled Trial in a Mildly Hypercholesterolemic Population. Mol Nutr Food Res. 2021 May; 65(9): e2001059. https://doi.org/10.1002/mnfr.202001059.
  79. Tong LT, Zhong K, Liu L, Guo L, Cao L, Zhou S. Oat oil lowers the plasma and liver cholesterol concentrations by promoting the excretion of faecal lipids in hypercholesterolemic rats. Food Chem. 2014, Jan 1, 142, 129-134. https://doi.org/10.1016/j.foodchem.2013.07.028.
  80. Hui S, Liu K, Lang H, Liu Y, Wang X, Zhu X, Doucette S, Yi L, Mi M. Comparative effects of different whole grains and brans on blood lipid: a network meta-analysis. Eur J Nutr. 2019 Oct; 58(7): 2779-2787. https://doi.org/10.1007/s00394-018-1827-6.
  81. Li Y, Qin C, Dong L, Zhang X, Wu Z, Liu L, Yang J, Liu L. Whole grain benefit: synergistic effect of oat phenolic compounds and β-glucan on hyperlipidemia via gut microbiota in high-fat-diet mice. Food Funct. 2022 Dec 13; 13(24): 12686-12696. https://doi.org/10.1039/d2fo01746f.
  82. Wang Y, Qi W, Guo X, Song G, Pang S, Fang W, Peng Z. Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats. Nutri-ents. 2022 Jul 4; 14(13): 2760. https://doi.org/10.3390/nu14132760.
  83. Gao H, Song RJ, Jiang H, Zhang W, Han SF. Oat fiber supplementation alleviates intestinal inflammation and ameliorates intestinal mucosal barrier via acting on gut microbiota-derived metabolites in LDLR-/- mice. Nutrition. 2022 Mar; 95: 111558. https://doi.org/10.1016/j.nut.2021.111558.
  84. Duan R, Guan X, Huang K, Zhang Y, Li S, Xia J, Shen M. Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice. J Agric Food Chem. 2021 Jul 14; 69(27): 7629-7640. https://doi.org/10.1021/acs.jafc.1c01813.
  85. Pavadhgul P, Bumrungpert A, Harjani Y, Kurilich A. Oat porridge consumption alleviates markers of inflammation and oxidative stress in hypercholesterolemic adults. Asia Pac J Clin Nutr. 2019; 28(2): 260-265. https://doi.org/10.6133/apjcn.201906_28(2).0008.
  86. Liao MY, Shen YC, Chiu HF, Ten SM, Lu YY, Han YC, Venkatakrishnan K, Yang SF, Wang CK. Down-regulation of partial substitution for staple food by oat noodles on blood lipid levels: A randomized, double-blind, clinical trial. J Food Drug Anal. 2019 Jan; 27(1): 93-100. https://doi.org/10.1016/j.jfda.2018.04.001.
  87. Amerizadeh A, Ghaheh HS, Vaseghi G, Farajzadegan Z, Asgary S. Effect of Oat (Avena sativa L.) Consumption on Lipid Profile With Focus on Triglycerides and High-density Lipoprotein Cholesterol (HDL-C): An Updated Systematic Review. Curr Probl Cardiol. 2023 Jul; 48(7): 101153. https://doi.org/10.1016/j.cpcardiol.2022.101153.
  88. Ho HV, Sievenpiper JL, Zurbau A, Blanco Mejia S, Jovanovski E, Au-Yeung F, Jenkins AL, Vuksan V. The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 2016 Oct;116(8):1369-1382. https://doi.org/10.1017/S000711451600341X.
  89. Zhu X, Sun X, Wang M, Zhang C, Cao Y, Mo G, Liang J, Zhu S. Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis. 2015, Aug., 25(8), 714-723. https://doi.org/10.1016/j.numecd.2015.04.008.
  90. Tong LT, Guo L, Zhou X, Qiu J, Liu L, Zhong K, Zhou S. Effects of dietary oat proteins on cholesterol metabolism of hypercholesterolaemic hamsters. J Sci Food Agric. 2016, Mar 15, 96(4), 1396-1401. https://doi.org/10.1002/jsfa.7236.
  91. Llanaj E, Dejanovic GM, Valido E, Bano A, Gamba M, Kastrati L, Minder B, Stojic S, Voortman T, Marques-Vidal P, Stoyanov J, Metzger B, Glisic M, Kern H, Muka T. Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials. Eur J Nutr. 2022 Jun; 61(4): 1749-1778. https://doi.org/10.1007/s00394-021-02763-1.
  92. Yu J, Xia J, Yang C, Pan D, Xu D, Sun G, Xia H. Effects of Oat Beta-Glucan Intake on Lipid Profiles in Hypercholesterolemic Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022 May 13; 14(10): 2043. https://doi.org/10.3390/nu14102043.
  93. Shehzad A, Rabail R, Munir S, Jan H, Fernández-Lázaro D, Aadil RM. Impact of Oats on Appetite Hormones and Body Weight Management: A Review. Curr Nutr Rep. 2023 Mar; 12(1): 66-82. https://doi.org/10.1007/s13668-023-00454-3.
  94. Sun NX, Tong LT, Liang TT, Wang LL, Liu LY, Zhou XR, Zhou SM. Effect of Oat and Tartary Buckwheat - Based Food on Cholesterol - Lowering and Gut Microbiota in Hypercholesterolemic Hamsters. J Oleo Sci. 2019 Mar 1; 68(3): 251-259. https://doi.org/10.5650/jos.ess18221.
  95. Sirotkin AV. The Effect of Dietary Oat Consumption and Its Constituents on Fat Storage and Obesity. Physiol Res. 2023 Jul 31; 72(Suppl 2): S157-S163.
  96. Cicero AFG., Fogacci F, Veronesi M, Strocchi E, Grandi E, Rizzoli E, Poli A, Marangoni F, Borghi C. A randomized Placebo-Controlled Clinical Trial to Evaluate the Medi-um-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Pro-file, Glycemia and in Testinal Health (BELT) Study. Nutrients. 2020 Mar 3; 12(3): 686. https://doi.org/10.3390/nu12030686.
  97. Han S, Gao H, Song R, Zhang W, Li Y, Zhang J. Oat Fiber Modulates Hepatic Circadian Clock via Promoting Gut Microbiota-Derived Short Chain Fatty Acids. J Agric Food Chem. 2021 Dec 29; 69(51): 15624-15635. https://doi.org/10.1021/acs.jafc.1c06130.
  98. Mathews R, Shete V, Chu Y. The effect of cereal Β-glucan on body weight and adiposity: A review of efficacy and mechanism of action. Crit Rev Food Sci Nutr. 2023; 63(19): 3838-3850. https://doi.org/10.1080/10408398.2021.1994523.
  99. Xochitl AF, Rosalía RC, Minerva RG, Mendoza-Sánchez M, Mora O, Pérez-Ramírez IF. Polyphenols and avenanthramides extracted from oat (Avena sativa L.) grains and sprouts modulate genes involved in glucose and lipid metabolisms in 3T3 L1 adipocytes. J Food Bio-chem. 2021 Jun; 45(6): e13738. https://doi.org/10.1111/jfbc.13738.
  100. Kato S, Kato Y, Shibata H, Saitoh Y, Miwa N. Repressive effects of oat extracts on intracellular lipid-droplet formation in adipocytes and a three-dimensional subcutaneous adipose tissue model. Mater Sci Eng C Mater Biol Appl. 2015, Apr., 49, 269-273. https://doi.org/10.1016/j.msec.2015.01.015.
  101. Ltaif M, Gargouri M, Magné C, El Feki A, Soussi A. Protective effects of Avena sativa against oxidative stress-induced kidney damage resulting from an estrogen deficiency in ovariectomized Swiss mice model. J Food Bio-chem. 2020 Jun; 44(6): e13205. https://doi.org/10.1111/jfbc.13205.
  102. El Shebini SM, Moaty MIA, Fouad S, Ahmed NH, Tapozada ST. Obesity Related Metabolic Disorders and Risk of Renal Disease: Impact of Hypocaloric Diet and Avena Sativa Supplement. Open Access Maced J Med Sci. 2018 Jul 29; 6(8): 1376-1381. https://doi.org/10.3889/oamjms.2018.292.
  103. Lee JC, AlGhawas DS, Poutanen K, Leung KS, Oger C, Galano JM, Durand T, El-Nezami H. Dietary Oat Bran Increases Some Proinflammatory Polyunsaturated Fatty-Acid Oxidation Products and Reduces Anti-Inflammatory Products in Apolipoprotein E-/- Mice. Lipids. 2018 Aug; 53(8): 785-796. https://doi.org/10.1002/lipd.12090.
  104. Leão LSCS, Aquino LA, Dias JF, Koifman RJ. Addition of oat bran reduces HDL-C and does not potentialize effect of a low-calorie diet on remission of metabolic syn-drome: A pragmatic, randomized, controlled, open-label nutritional trial. Nutrition. 2019 Sep; 65: 126-130. https://doi.org/10.1016/j.nut.2019.03.007.

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