Вестник фундаментальной и клинической медицины , 2024, № 5 (11)
Тема статьи
РОЛЬ МИКРОЭЛЕМЕНТОВ ПРИ ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЯХ ПЕЧЕНИ (113-121)
Авторы
Джаббаров З.И.
Учреждение
Бухарский филиал Республиканского научного центра неотложной скорой помощи
Аннотация
В этом обзоре мы обобщили современное понимание конкретных микроэлемен-тов и их связи с хроническими заболеваниями печени.
Ключевые слова
печень, микроэлементы, железо, селен, цинк, магний, морфология.
Литературы
- Berger MM, Shenkin A, Schweinlin A, Amrein K, Augsburger M, Biesalski HK, et al. ESPEN micronutrient guideline. Clin Nutr. 2022;41(6):1357–424. https://doi.org/10.1016/j.clnu.2022.02.015.
- Bischoff SC, Bernal W, Dasarathy S, Merli M, Plank LD, Schütz T, et al. ESPEN practical guideline: clinical nutrition in liver disease. Clin Nutr. 2020;39(12):3533–62. https://doi.org/10.1016/j. clnu.2020.09.001.
- Bjelakovic M, Nikolova D, Bjelakovic G, Gluud C. Vitamin D supplementation for chronic liver diseases in adults. Cochrane Data-base Syst Rev. 2021;2021(10). https://doi.org/10.1002/ 14651858.cd011564.pub3.
- Blaner WS. Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders. Pharmacol Ther. 2019;197:153– 78. https://doi.org/10.1016/j.pharmthera.2019.01.006
- Bloom A, Bloom S, Silva H, Nicoll AJ, Sawhney R. Zinc supplementation and its bene-fits in the management of chronic liver disease: an in-depth literature review. Ann Hepatol. 2021;25:100549. https://doi.org/10.1016/j.aohep.2021.100549.
- Carvalho L, Parise ER. Evaluation of nutritional status of nonhospitalized patients with liver cirrhosis. Arq Gastroenterol. 2006;43(4):269– 74. https://doi.org/10.1590/s0004-28032006000400005.
- Cheung K, Lee SS, Raman M. Preva-lence and mechanisms of malnutrition in patients with advanced liver disease, and nutrition management strategies. Clin Gastroenterol Hepatol. 2012;10(2):117–25. https://doi.org/10.1016/j.cgh.2011.08.016.
- Diglio DC, Fernandes SA, Stein J, Azeredo-da-Silva A, de Mattos AA, Tovo CV. Role of zinc supplementation in the management of chronic liver diseases: a systematic re-view and meta-analysis. Ann Hepatol. 2020;19(2):190–6. https:// doi.org/10.1016/j.aohep.2019.08.011.
- Fang A, Zhu H. Serum copper and zinc levels and risk of hepatocellular carcinoma: a 1:1 matched case-control study. Curr Dev Nutr. 2020;4:nzaa061_25. https://doi.org/10.1093/cdn/nzaa061_025.
- Finkelmeier F, Kronenberger B, Zeuzem S, Piiper A, Waidmann O. Low 25-Hydroxyvitamin D levels are associated with infections and mortality in patients with cirrhosis. PLOS ONE. 2015;10(6): e0132119. https://doi.org/10.1371/journal.pone.0132119.
- Gad AI, Elmedames MR, Abdelhai AR, Marei AM. The association between vitamin D status and non-alcoholic fatty liver disease in adults: a hospital-based study. Egypt Liver J. 2020;10(1). https://doi.org/10.1186/s43066-020-00033-z.
- Gaussin V, Gailly P, Gillis JM, Hue L. Fructose-induced increase in intracellular free Mg2+ ion concentration in rat hepatocytes: relation with the enzymes of glycogen metabolism. Biochem J 1997; 326: 823-827 [PMID: 9307033 DOI: 10.1042/bj3260823]
- Grover I, Gunjan D, Singh N, Benja-min J, Ramakrishnan L, Pandey RM, et al. Effect of vitamin D supplementation on vitamin D level and bone mineral density in patients with cirrhosis: a randomized clinical trial. Am J Gastroenterol. 2021;116(10):2098– 104. https://doi.org/10.14309/ajg.0000000000001272.
- Grüngreiff K, Reinhold D, Wedemeyer H. The role of zinc in liver cirrhosis. Ann Hepatol. 2016;15(1):7–16. https://doi.org/10.5604/16652681.1184191.
- Jacobs ET, Lance P, Mandarino LJ, Ellis NA, Chow HHS, Foote J, et al. Selenium supplementation and insulin resistance in a randomized, clinical trial. BMJ Open Diabetes Res Care. 2019;7(1):e000613. https://doi.org/10.1136/ bmjdrc-2018-000613.
- Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J 2012; 5: i3-i14 [PMID: 26069819 DOI: 10.1093/ndtplus/sfr163]
- Kataria Y, Deaton RJ, Enk E, Jin M, Petrauskaite M, Dong L, et al. Retinoid and ca-rotenoid status in serum and liver among patients at high-risk for liver cancer. BMC Gastroenterol. 2016;16(1). https://doi.org/10.1186/s12876-016-0432-5.
- Koop AH, Mousa OY, Pham LE, Corral-Hurtado JE, Pungpapong S, Keaveny AP. An argument for vitamin D, A, and sinc monitoring in cirrhosis. Ann Hepatol. 2018;17(6):920–32. https://doi.org/10.5604/01.3001.0012.7192.
- Kubesch A, Quenstedt L, Saleh M, Rüschenbaum S, Schwarzkopf K, Martinez Y, et al. Vitamin D deficiency is associated with hepatic decompensation and inflammation in patients with liver cirrhosis: a prospective cohort study. PLOS ONE. 2018;13(11):e0207162. https://doi.org/10.1371/journal.pone.0207162.
- Kubota H, Chiba H, Takakuwa Y, Osanai M, Tobioka H, Kohama G, et al. Retinoid X receptor alpha and retinoic acid receptor gamma mediate expression of genes encoding tight junction proteins and barrier function in F9 cells during visceral endodermal differentiation. Exp Cell Res. 2001;263(1):163–72. https://doi.org/10.1006/excr.2000.5113.
- L, et al. Mortality risk factors among patients with cirrhosis and a low model for end-stage liver disease sodium score (≤15): an analysis of liver transplant allocation policy using aggregated electronic health record data. Am J Transplant. 2017;17(9):2410–9. https://doi.org/10.1111/ajt.14239.
- Lai JC, Tandon P, Bernal W, Tapper EB, Ekong U, Dasarathy S, et al. Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the American Association for the Study of Liver Diseases. Hepatolo-gy. 2021;74(3):1611–44. https://doi.org/10.1002/hep.32049
- Licata A, Zerbo M, Como S, Cammilleri M, Soresi M, Montalto G, et al. The role of vitamin deficiency in liver disease: to supplement or not supplement? Nutrients. 2021;13(11):4014. https://doi.org/10.3390/nu13114014.
- Lin Y, He F, Lian S, Xie B, Liu T, He J, et al. Selenium status in patients with chronic liver disease: a systematic review and meta-analysis. Nutrients. 2022;14(5):952. https://doi.org/10. 3390/nu14050952.
- Llibre-Nieto G, Lira A, Vergara M, Solé C, Casas M, Puig-Diví V, et al. Micronutrient deficiencies in patients with decompensated liver cirrhosis. Nutrients. 2021;13(4):1249. https://doi.org/10.3390/nu13041249
- Merli M, Giusto M, Gentili F, Novelli G, Ferretti G, Riggio O, et al. Nutritional status: its influence on the outcome of patients under-going liver transplantation. Liver Int. 2010;30(2):208–14. https://doi.org/10.1111/j.1478-3231.2009.02135.x.
- Merli M, Riggio O, Dally L. Does malnutrition affect survival in cirrhosis? Hepatology. 1996;23(5):1041–6. https://doi.org/ 10.1002/hep.510230516
- Mohamed AA, Al-Karmalawy AA, El-Kholy AA, El-Damas DA, Abostate HM, Mosta-fa SM, et al. Effect of Vitamin D supplementation in patients with liver cirrhosis having spontaneous bacterial peritonitis: a randomized con-trolled study. Eur Rev Med Pharmacol Sci. 2021;25(22):6908–19. https://doi.org/10.26355/eurrev_202111_27239..
- Nishikawa H, Asai A, Fukunishi S. The significance of zinc in patients with chronic liver disease. Nutrients. 2022;14(22):4855. https://doi.org/10.3390/nu14224855.
- Ordak M, Maj-Zurawska M, Matsu-moto H, Bujalska-Zadrozny M, Kieres-Salomonski I, Nasierowski T, Muszynska E, Wojnar M. Ionized magnesium in plasma and erythrocytes for the assessment of low magnesium status in alcohol dependent patients. Drug Alcohol Depend 2017; 178: 271-276 [PMID: 28683422 DOI: 10.1016/j.drugalcdep.2017.04.035]
- Paternostro R, Wagner D, Reiberger T, Mandorfer M, Schwarzer R, Ferlitsch M, et al. Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis. Wien Klin Woch-enschr. 2017;129(1–2):8–15. https://doi.org/10.1007/s00508-016-1127-1.
- Perumpail B, Li A, John N, Sallam S, Shah N, Kwong W, et al. The role of vitamin E in the treatment of NAFLD. Diseases. 2018;6(4):86. https://doi.org/10.3390/diseases6040086.
- Reja M, Makar M, Visaria A, Marino D, Rustgi V. Increased serum selenium levels are associated with reduced risk of advanced liver fibrosis and all-cause mortality in NAFLD patients: National Health and Nutrition Examination Surve (NHANES) III. Ann Hepatol. 2020;19(6):635–40. https://doi. org/10.1016/j.aohep.2020.07.006. Third Nation-al Health and
- Romani AM, Scarpa A. Regulation of cellular magnesium. Front Biosci 2000; 5: D720-D734 [PMID:10922296 DOI: 10.2741/romani]
- Rylander R, Mégevand Y, Lasserre B, Amstutz W, Granbom S. Moderate alcohol consumption and urinary excretion of magnesium and calcium. Scand J Clin Lab Invest 2001; 61: 401-405 [PMID: 11569488 DOI: 10.1080/003655101316911459]
- Saeed A, Bartuzi P, Heegsma J, Dek-ker D, Kloosterhuis N, De Bruin A, et al. Im-paired hepatic vitamin A metabolism in NAFLD mice leading to vitamin A accumulation in hepatocytes. Cell Mol Gastroenterol Hepatol. 2021;11(1):309-25.e3. https://doi.org/10.1016/j.jcmgh.2020.07.006.
- Schomburg L, Schweizer U, Köhrle J. Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic. Cell Mol Life Sci. 2004;61(16):1988–95. https://doi.org/10.1007/ s00018-004-4114-z.
- Shi Z, Abou-Samra AB. Association of low serum magnesium with diabetes and hypertension: Findingsfrom Qatar Biobank study. Diabetes Res Clin Pract 2019; 158: 107903 [PMID: 31678625 DOI: 10.1016/j.diabres.2019.107903]
- Shih C-W, Chen Y-J, Chen W-L. Inverse association between serum selenium level and severity of liver fibrosis: a cross-sectional study. Nutrients. 2022;14(17):3625. https://doi.org/10. 3390/nu14173625.
- Simbrunner B, Semmler G, Stadlmann A, Scheiner B, Schwabl P, Paternostro R, et al. Vitamin A levels reflect disease severity and portal hypertension in patients with cirrhosis. Hep Intl. 2020;14(6):1093–103. https://doi.org/10.1007/s12072-020-10112-3.
- Song J, Jiang ZG. Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study. Hepatol Commun. 2023;7(5). https://doi.org/10.1097/hc9.00000 00000000124. A large cohort study demonstrating the association between retinol deficiency and liver fibrosis and liverrelated mortality.
- Steinbrenner H, Duntas LH, Rayman MP. The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities. Redox Biol. 2022;50:102236. https://doi.org/10.1016/j.redox.2022.102236.
- Stokes CS, Krawczyk M, Reichel C, Lammert F, Grünhage F. Vitamin D deficiency is associated with mortality in patients with advanced liver cirrhosis. Eur J Clin Invest. 2014;44(2):176– 83. https://doi.org/10.1111/eci.12205.
- Tsiaousi ET, Hatzitolios AI, Trygonis SK, Savopoulos CG. Malnutrition in end stage liver disease: recommendations and nutritional support. J Gastroenterol Hepatol. 2008;23(4):527– 33. https://doi.org/10.1111/j.1440-1746.2008.05369.x.
- Young A, Cefaratti C, Romani A. Chronic EtOH administration alters liver Mg2+ homeostasis. Am J Physiol Gastrointest Liver Physiol 2003; 284: G57-G67 [PMID: 12488234 DOI: 10.1152/ajpgi.00153.2002] Atiemo K, Skaro A, Maddur H, Zhao L, Montag S, Vanwagner
- Zafar MS, Wani JI, Karim R, Mir MM, Koul PA. Significance of serum magnesium levels in critically ill patients. Int J Appl Basic Med Res 2014; 4: 34-37 [PMID: 24600576 DOI: 10.4103/2229-516X.125690]
- Zhang Z, Wu L, Wang G, Hu P. Effect of vitamin D deficiency on spontaneous peritonitis in cirrhosis: a meta-analysis.220 Current Hepatology Reports (2023) 22:216–220 1 3 Gastroenterol Rev. 2021;16(1):10–4. https://doi.org/10.5114/pg. 2020.101632