Фундаментал ва клиник тиббиёт ахборотномаси , 2024, №6 (12)

Maqola mavzusi

COVID-19 INFEKTSIYASI FONIDA O’RS BILAN KASALLANGAN BEMORLARDA IMMUN STATUS HOLATI (52-59)

Mualliflar

Narzullaev N.U.

Muassasa

Buxoro davlat tibbiyot instituti

Annotatsiya

COVID-19 infektsiyasi fonida O’RS bilan kasallangan 25 nafar bemorlarda immunitet holati o'rganildi. Nazorat guruhini 14 nafar sog'lom bemorlar tashkil etdi. O’RS bilan kasallangan bemorlarda immunitetning chuqur buzilishlari, ayniqsa immunitetning T-bo'g'inlari va uning subpopulyatsiyalari, shuningdek, immunitetning gumoral bog'lanishining buzilishi, yallig'lanishga qarshi sitokinning bostirilishi aniqlangan. IL-10 va yallig'lanishga qarshi IFN-g ning ko'payishi kuzatildi. O'tkazilgan davolanishning ta'siri ostida bemorlarda immunitet holatida aniq o'zgarishlar aniqlanmadi. Biz faqat IL-10 tarkibidagi ijobiy o'zgarishlarni va davolash dinamikasida IFN-g ning parallel pasayishini aytishimiz mumkin.

Kalit so'zlar

immunitet holati, COVID-19, o'tkir rinosinusit, hujayra immuniteti, gumoral immunitet, immunitet tanqisligi, sitokinlar.

Adabiyotlar

  1. Aripova T.U., Ismailova A.A. COVID-19: possibilities of immunotherapy : review / // Journal of Theoretical and Clinical Medicine : scientific and practical medical journal / Academy of Sciences of the Republic of Uzbekistan. - Tashkent : Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan. - 2020. - No. 3. - Р. 8-12.
  2. Assanovich M.A. Escitalopram in pharmacotherapy of mental disorders in patients with COVID-19 //Medical news. 2021. No. 1 (316). - pp. 59-62.
  3. Bazdyrev E.D. Coronavirus infection - an urgent problem of the XXI century //Complex problems of cardiovascular diseases. 2020. Vol. 9. No. 2. - pp. 6-16.
  4. Bachilo E.V. Mental health of the population during the COVID-19 pandemic //Journal of Neurology and Psychiatry named after C.C. Korsakov. 2020. Vol. 120. No. 10.- pp. 130-136.
  5. Bekzhanova O.E., Kayumova V.R., Alimova S.H. Clinical and pathogenetic aspects of olfaction and taste disorders in COVID-19.Tashkent State Dental Institute-2021.-pp.67-74.
  6. Belyakov N.A., Rassokhin V.V., Yastrebova E.B. Coronavirus infection COVID-19. the nature of the virus, pathogenesis, clinical manifestations. message 1 //HIV infection and immunosuppression. 2020. Vol. 12. No. 1. - pp. 7-21.
  7. Demyanov A.V. V. et al. diagnostic value of the study of cytokine levels in clinical practice. // Cytokines and inflammation. - 2003 No. 3. – pp. 20-23.
  8. Lantsov A.A., Khmelnitskaya N.M., Endaltseva E.B. Local immunity and treatment of patients with chronic purulent otitis media // News of otorhinolaryngology and logopathology. -1999. – No. 1. – pp. 3-7.
  9. Narzulaev N.U., Khamidova N.K., Mirzayeva M.R. Clinical and immunological study of the effect of various types of therapy on the course of allergic rhinitis in children with hymenolepidosis// Annals of the Romanian Society of Cell Biology 2021. pp. 1900-1908.
  10. Narzulaev N.U., Mirzayeva M.R. Immunological features of infectious mononucleosis Epstein-Barr virus etiology in children// International Journal of Pharmaceutical Research 2021, pp 2667-2671.
  11. Narzullaev N.U., Rakhmatov A.A. Cytokine profile in children with acute inflammation of the middle earth on the background of chronic active hepatitis // Tibbietda yangi kun. No. 2 (34). Tashkent 2021, pp.15-17.

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