Maqola mavzusi

Mualliflar

Tilavov T.B. Xasanova D.A.

Muassasa

Abu Ali ibn Sino nomidagi Buxoro davlat tibbiyot instituti, Buxoro sh., O‘zbekiston

Annotatsiya

Surunkali buyrak yetishmovchiligi (SBY) — bu odatda jinsiy tizimning buzilishi, shu jumladan moyaklarning atrofiyasi va spermatogenezning buzilishi bilan kechadigan progres-siv patologik holatdir. Ushbu tadqiqotda tajriba yo‘li bilan surunkali buyrak yetishmovchiligi chaqirilgan erkak oq albi nos kalamushlarning moyaklarida yuz beradigan morfometrik va morfologik o‘zgarishlar hamda sumbul ildizi (Ferula moschata) ekstraktining davolovchi ta’siri o‘rganildi. Tadqiqot 140 ta oq zotsiz kalamushlarda o‘tkazildi. Ular 3, 6 va 9 oylik bo‘lgan uch yosh guruhiga bo‘lindi. Har bir yosh guruhida kalamushlar nazorat, SBY modeli va davolovchi kichik guruhlarga ajratildi. Surunkali buyrak yetishmovchiligi standart nefrotoksik vositalar yordamida chaqirildi. Davolovchi guruhlarga ma’lum muddat davomida sumbul ildizi ekstrakti berildi. Moyaklar umumiy anatomik, gistologik va morfometrik tahlil uchun yig‘ildi. Moyak vazni, kapsula qalinligi, urug‘ yo‘llari diametri va yuzasi, epiteliy-spermatogen qatlam qalinligi kabi ko‘rsatkichlar o‘lchandi. Shuningdek, epiteliy qatlami va kanalcha bo’shlig’i nisbati ham hisoblandi. Davolanmagan SBY kalamushlarida moyak to‘qimalarida sezilarli atrofik o‘zgarishlar aniqlandi: urug‘ yo‘llari diametrining kichrayishi, spermatogen qatlamning yupqalashuvi va a’zoning og‘irligining kamayishi kuzatildi. 3 oylik kalamushlarda sumbul ildizi ekstrakti qo‘llanilganda moyak tuzilmasi va morfometrik ko‘rsatkichlar sezilarli darajada tiklandi va nazorat guruhiga yaqinlashdi. 6 oylik kalamushlarda davolovchi ta’sir o‘rtacha dara jada bo‘ldi, 9 oylik kalamushlarda esa cheklangan ta’sir kuzatildi, bu esa yoshga bog‘liq regenerativ javobni aks ettiradi. Sumbul ildizi ekstrakti SBY natijasida yuzaga kelgan moyak shikastlanishini bartaraf etishda yoshga bog‘liq terapevtik salohiyatni namoyon etadi. Erta boshlangan muolaja morfofunktsional tiklanishni kuchliroq namoyon qiladi, bu esa uni SBY bilan bog‘liq jinsiy bez faoliyatining buzilishida istiq bolli fitoterapevtik vosita sifatida ko‘rsatadi.

Kalit so'zlar

Surunkali buyrak yetishmovchiligi, moyak morfologiyasi, morfometriya, Ferula moscha ta, sumbul ildizi ekstrakti, urug‘ yo‘llari, spermatogenez, kalamush modeli, yoshga bog‘liq regeneratsiya, fitoterapiya.

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