Maqola mavzusi

Mualliflar

Gʻoyibov S.S., Abduvaliyeva N.B.

Muassasa

Samarqand davlat tibbiyot universiteti, Samarqand sh., O`zbekiston

Annotatsiya

Muddatdan oldingi tugʻruq bu zamonaviy akusherlikning muhim muammolaridan biri boʻlib, perinatal kasallanish va oʻlimning asosiy sabablaridandir. Muddatdan oldingi tugʻruqlarning uchdan ikki qismi tugʻruq faoliyatining spontan boshlanishi bilan sodir boʻladi. Spontan muddatdan oldingi tugʻruq bu koʻplab sabablar tufayli kelib chiqadigan, jumladan, progesteron ta’sirining pasayishi sababli bachadon boʻynining yetilishi sindromi. Homiladorlikning ikkinchi yarmida oʻtkazilgan bachadon boʻyni exografiyasi spontan muddatdan oldingi tugʻruqning asosiy prognozlash me’zoni hisoblanadi. Oʻtkazilgan koʻplab izlan ishlar shuni koʻrsatadiki, homiladorlikning 33 haftasigacha vaginal progesteronni qoʻllash, muddatdan oldingi tugʻruqni 42% gacha kamaytiradi hamda yangi tugʻilgan chaqaloqlarning intensiv terapiyaga mu htojligini, respirator distress sindromni, sun’iy nafas berish apparati kerakligini va neonatal oʻlim koʻrsatgichini pasaytiradi. Muddatdan oldingi tugʻruqda bachadon boʻyni kaltaligini tashxislashda ultra tovushni qoʻllash, vaginal progesterondan foydalanish bachadon boʻyni kalta boʻlgan ayollarda ham iqti sodiy, ham effektiv ta’sir koʻrsatganligi, ushbu amaliyotni qoʻllashga ehtiyoj sezdirdi.

Kalit so'zlar

vaginal progesteron, muddatdan oldingi tugʻruq, bachadon boʻyni choklari.

Adabiyotlar

1. Andersen H.F., Nugent C.E., Wanty S.D., Hayashi R.H. Prediction of risk for preterm delivery by ultrasonographic measurement of cervical length // Am. J. Obstet. Gynecol. - 2020. - Vol. 163. - P. 859-867.
2. Arabin B., Halbesma J.R., Vork F. et al. Is treatment with vaginal pessaries an option in patients with a sonographically detected short cervix? // J. Perinat. Med. - 2023. - Vol. 31. - P. 122-133.
3. Botsis D., Papagianni V., Vitoratos N. et al. Prediction of preterm delivery by sono-graphic esti mation of cervical length // Biol. Neonate. - 2020. - Vol. 88. - P. 42-45.
4. Carlomagno G., Di Blasi A., Monica M.D. Congenital scolio-sis associated with agenesis of the uterine cervix. Case report // BMC Womens Health. - 2021. - Vol. 4. - P. 4.
5. Conde-Agudelo A., Romero R., Kusanovic J.P. Nifedipine in the management of preterm labor: a systematic review and metaanalysis // Am. J. Ob stet. Gynecol. - 2021. -Vol. 204. -P. 134. e1-20.
6. Fonseca E.B., Celik E., Parra M. et al. Progesterone and the risk of preterm birth among women with a short cervix // N. Engl. J. Med. - 2023. - Vol. 357.-P. 462-469
7. Goldenberg R.L., Culhane J.F., Iams J.D., Romero R. Epidemiology and causes of preterm birth // Lancet. -2022. - Vol. 371. - P. 75-84.
8. Grobman W. Randomized controlled trial of progesterone treat ment for preterm birth preven tion in nulliparous women with cervical length less than 30 mm // Am. J. Obstet. Gynecol. - 2022. - Vol. S367.
9. Iams J.D., Newman R.B., Thom E.A. et al. Frequency of uterine contractions and the risk of spontaneous preterm delivery // N. Engl. J. Med. - 2022. -Vol. 346. -P. 250-255
10. Haran G., Elbaz M., Fejgin M.D., Biron Shental T. A compari son of surface acquired uterine electromyography and intra-uterine pressure catheter to assess uterine activity // Am. J. Obstet. Gynecol. - 2022. -Vol. 206. - P. 412.
11. Keirse M.J. Progesterone and preterm: seventy years of “déjà vu” or “still to be seen”? // Birth. - 2021. - Vol. 31. -P. 230-235.
12. Lee S.E., Romero R., Park C.W. et al. The frequency and signifi cance of intraamniotic infl ammation in patients with cervical insuffi ciency // Am. J. Obstet. Gynecol. -2024. - Vol. 198. - P. 633.
13. Mahendroo M. Cervical remodeling in term and preterm birth: insights from an animal model // Reproduction. - 2022. - Vol. 143. - P. 429 438.
14. Mays J.K., Figueroa R., Shah J. et al. Am niocentesis for selection before rescue cerclage // Obstet. Gynecol. -2020. - Vol. 95. - P. 652-655.
15. Ogge G., Romero R., Lee D.C. et al. Chronic chorioamnionitis displays distinct altera tions of the amniotic fluid proteome // J. Pathol. - 2021. - Vol. 223. - P. 553-565.
16. Riley R.D., Lambert P.C., Abo-Zaid G. Meta-analysis of indi vidual participant data: ra tionale, conduct, and reporting // Br. Med. J. - 2020. - Vol. 340. - P. c221.
17. Saling E. Prevention of prematurity – a complex undertaking reply // J. Perinat. Med. - 2022. - Vol. 40. -P. 103.
18. Sutton A.J., Kendrick D., Coupland C.A. Meta-analysis of indi vidual- and aggregate-level data // Stat. Med. -2021. - Vol. 27. - P. 651-669.
19. Timmons B., Akins M., Mahendroo M. Cervical remodeling during pregnancy and parturi tion // Trends Endocrinol. Metab. - 2020. -Vol. 21. - P. 353-361.
20. Werner E.F., Han C.S., Pettker C.M. et al. Universal cervical-length screening to prevent pre term birth: a costeffectiveness analysis // Ultrasound Obstet. Gynecol. -2021. -Vol. 38. - P. 32-37.
21. Wood S., Ross S., Tang S. et al. Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial // J. Peri nat. Med. – 2022.
22. Word R.A., Li X.H., Hnat M., Carrick K. Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts // Semin. Reprod. Med. -2023. - Vol. 25. - P .69-79.