Фундаментал ва клиник тиббиёт ахборотномаси 2025, №3 (17)

Maqola mavzusi

BACHADON LEYOMIOMASI RIVOJLANISHINING MOLEKULYAR ASOSLARI (332-337)

Mualliflar

Хайдарова Ф.А., Рахматуллаева М.М.

Muassasa

Бухарский государственный медицинский институт имени Абу Али ибн Сино, г. Бухара, Узбекистан

Annotatsiya

Sharhda bachadon leiomyomasining o'sishi va rivojlanish mexanizmlarini o'rganishga bag'ishlangan nashrlar tahlili keltirilgan. Ushbu kasallikning patogenezining keng talqin qilinadigan jihatlari ko'rib chiqiladi, unga ko'ra bachadon leyomiomasining rivojlanishiga jinsiy gormonlar darajasining oshishi, ularning retseptorlari ekspressiyasining kuchayishi, o'sish omillarining ta'siri, hujayra tashqarisidagi matriksning ortiqcha to’planishi, uzoq muddatli gipoksiya va yallig'lanish stressi tufayli o’zak hujayralari populyatsiyasidan miyometriy hujayralari shakllanishining genetik buzilishi olib kelishi mumkin. Ushbu patologiya patogenezining murakkabligi batafsil o'rganishni talab qiladi, bu miomani davolash va oldini olishni yaxshilashga yordam beradi, deb ta'kidlanadi.

Kalit so'zlar

bachadon leyomiomasi, jinsiy steroidlar, miofibroblast, hujayradan tashqari matritsa, o'sish omillari.

Adabiyotlar

  1. Аганезова Н.В., Аганезов С.С., Шило М.М. Миома матки: современные практические аспекты заболевания // Проблемы репродукции. – 2022. – №28(4). – С.97-105.
  2. Тихомиров А.Л., Казенашев В.В., Мак симова О.В. и др. Преимущества, недостатки и оптимизация органосохраняющих методов лече ния миомы матки // Акушерство, гинекология и репродукция. – 2024. – №18(5). – С.635-647.
  3. Тюрина А.А., Ящук А.Г., Имельбаева А.Г., Яковлева О.В. Роль прогестерона и ткане вых факторов роста в патогенезе миомы матки // Практическая медицина. – 2018. – Т.16, № 6. – С. 124-129.
  4. Aimagambetova G, Bapayeva G, Uky bassova T, Zemlyanskiy V, Gusmanov A, Terzic M. The role of VEGF and TGF-β blood levels for fi broid shrinkage, menorrhagia score, and quality of life improvement after uterine artery embolization for uterine fibroids: a study protocol. Med. 2024;11:1382822.
  5. Al Kinani MJH, Al-Badri AMS. The po tential of transforming growth factor-beta1 (TGFβ1) in fibrotic tissue of leiomyoma specimens. South Eastern European Journal of Public Health. 2024;587–596.
  6. Ali M, Ciebiera M, Vafaei S, Alkhrait S, Chen H-Y, Chiang Y-F, et al. Progesterone signaling and uterine fibroid pathogenesis: molecular mechanisms and potential therapeutics. 2023;12(8):1117.
  7. Boichuk S, Dunaev P, Galembikova A, Valeeva E. Fibroblast growth factor 2 (FGF2) acti vates vascular endothelial growth factor (VEGF) signaling in gastrointestinal stromal tumors (GIST): an autocrine mechanism contributing to imatinib mesylate (im) resistance. 2024;16(17):3103.
  8. Borahay MA, Asoglu MR, Mas A, Adam S, Kilic GS, Al-Hendy A. Estrogen receptors and signaling in fibroids: role in pathobiology and thera peutic implications. Reprod Sci. 2017;24(9):1235 1244.
  9. Cialdai F, Risaliti C, Monici M. Role of fi broblasts in wound healing and tissue remodeling on Earth and in space. Front Bioeng Biotechnol. 2022;10:958381.
  10. Ciebiera M, Włodarczyk M, Wrzosek M, Męczekalski B, Nowicka G, Łukaszuk K, et al. Role of transforming growth factor β in uterine fibroid biology. Int J Mol Sci. 2017;18(11):2435.
  11. Dolmans MM, Petraglia F, Catherino WH, Donnez J. Pathogenesis of uterine fibroids: current understanding and future directions. Fertil Steril. 2024;122(1):6-11.
  12. Emrahi L, Behroozi J, Shahbazi S. Expres sion study of CYP19A1 gene in a cohort of Iranian leiomyoma patients. Egyptian Journal of Medical Human Genetics. 2018;19(3):197-200.
  13. Goad J, Rajkovic A. Uterine fibroids at single-cell resolution: unveiling cellular heterogenei ty to improve understanding of pathogenesis and guide future therapies. Am J Obstet Gynecol. 2025;232(4S):S124-S134.
  14. Holdsworth-Carson SJ, Zaitseva M, Vol lenhoven BJ, Rogers PA. Clonality of smooth mus cle and fibroblast cell populations isolated from hu man fibroid and myometrial tissues. Mol Hum Re prod. 2014;20(3):250-259.
  15. Idowu BM, Ibitoye BO. Doppler sonogra phy of perifibroid and intrafibroid arteries of uterine leiomyomas. Obstet Gynecol Sci. 2018;61(3):395 403.
  16. Islam MS, Protic O, Stortoni P, Grechi G, Lamanna P, Petraglia F, Castellucci M, Ciarmela P. Complex networks of multiple factors in the patho genesis of uterine leiomyoma. Fertil Steril. 2013;100(1):178-193.
  17. Islam MS, Ciavattini A, Petraglia F, Cas tellucci M, Ciarmela P. Extracellular matrix in uter ine leiomyoma pathogenesis: a potential target for future therapeutics. Hum Reprod Update. 2018;24(1):59-85.
  18. Ishikawa H, Xu L, Sone K, Kobayashi T, Wang G, Shozu M. Hypoxia induces hypoxia inducible factor 1α and potential HIF-responsive gene expression in uterine leiomyoma. Reprod Sci. 2019;26(3):428-435.
  19. Konarska M, Wrona AN, Aleksandrovych V, Bereza T, Sajewicz M, Gach-Kuniewicz B, et al. Angiogenesis and pro-angiogenic factors in uterine fibroids - facts and myths. Folia Med Cracov. 2016;56(2):37-43.
  20. Machado-Lopez A, Simón C, Mas A. Mo lecular and cellular insights into the development of uterine fibroids. Int J Mol Sci. 2021;22(16):8483.
  21. Moravek MB, Yin P, Ono M, Coon JS, Dyson MT, Navarro A, et al. Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implica tions. Hum Reprod Update. 2015;21(1):1-12.
  22. Narwal S, Vashist M, Kaushik R, Siwach K, Hooda R. Prediction, prevention, susceptibility of estrogen receptor alpha gene polymorphism towards uterine leiomyoma development. Journal of Cancer Science and Clinical Therapeutics. 2024;8:232-238.
  23. Niauri D, Dzhemlikhanova L, Gzgzyan A, Osinovskaya N, Gorovaya E, Ivashchenko T, et al. Catechol-O-methyltransferase polymorphism (VAL158MET) in women with uterine leiomyoma and adenomyosis. Vestnik of Saint Petersburg Uni versity. Medicine. 2016;11(3):103–110.
  24. Olson SL, Akbar RJ, Gorniak A, Fuhr LI, Borahay MA. Hypoxia in uterine fibroids: role in pathobiology and therapeutic opportunities. Oxygen (Basel). 2024;4(2):236-252.
  25. Ono M, Yin P, Navarro A, Moravek MB, Coon JS, Druschitz SA, et al. Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth. Proc Natl Acad Sci USA. 2013;110(42):17053-8.
  26. Orciani M, Caffarini M, Biagini A, Luca rini G, Delli Carpini G, Berretta A, et al. Chronic inflammation may enhance leiomyoma development by the involvement of progenitor cells. Stem Cells International. 2018;2018:1716246.
  27. Protic O, Toti P, Islam MS, Occhini R, Gi annubilo SR, Catherino WH, et al. Possible in volvement of inflammatory/reparative processes in the development of uterine fibroids. Cell and Tissue Research. 2016;364(2):415-427.
  28. Protic O, Islam MS, Greco S, Giannubilo SR, Lamanna P, Petraglia F, et al. Activin A in in flammation, tissue repair, and fibrosis: Possible role as inflammatory and fibrotic mediator of uterine fi broid development and growth. Semin Reprod Med. 2017;35(6):499-509.
  29. Rafique S, Segars JH, Leppert PC. Me chanical signaling and extracellular matrix in uterine fibroids. Semin Reprod Med. 2017;35(6):487-493.
  30. Reis FM, Bloise E, Ortiga-Carvalho TM. Hormones and pathogenesis of uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016;34:13-24.
  31. Sato S, Maekawa R, Yamagata Y, Tamura I, Lee L, Okada M, et al. Identification of uterine leiomyoma-specific marker genes based on DNA methylation and their clinical application. Sci Rep. 2016;6:30652.
  32. Shen Y, Lu Q, Zhang P, Wu Y, Ren M. The effect of TGF-β signaling on regulating prolif eration of uterine leiomyoma cell via ERα signaling activated by bisphenol A, octylphenol and nonylphenol in vitro. J Cancer Res Ther. 2018;14(2):S276-S281.
  33. Stewart EA, Laughlin-Tommaso SK, Catherino WH, Lalitkumar S, Gupta D, Vollenhoven B. Uterine fibroids. Nat Rev Dis Primers. 2016;2:16043.
  34. Szucio W, Bernaczyk P, Ponikwicka Tyszko D, Milewska G, Pawelczyk A, Wołczyński S, et al. Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy. Adv Med Sci. 2024;69(1):21-28.
  35. Vallée A, Lecarpentier Y. TGF-β in fibro sis by acting as a conductor for contractile properties of myofibroblasts. Cell Biosci. 2019;9:98.
  36. Upadhyay S, Dubey PK. Gene variants polymorphisms and uterine leiomyoma: an updated review. Front. Genet. 2024;15:1330807.
  37. Yang Q, Al-Hendy A. Update on the role and regulatory mechanism of extracellular matrix in the pathogenesis of uterine fibroids. Int J Mol Sci. 2023;24(6):5778.

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