​Femoral fractures in elderly patients: predicting complications prior to surgery
​A new method developed by scientists from the Bukhara State Medical Institute named after Abu Ali ibn Sina has been recognized as an invention by the Ministry of Justice of the Republic of Uzbekistan and protected under patent UZ IAP 8627.

​Where did the problem begin?
Femoral fractures are among the most common and severe injuries occurring in elderly and senile individuals. According to scientific literature, conservative management involving prolonged bed rest carries a mortality rate of no less than 40%. Therefore, the primary treatment strategy relies on surgical intervention—securing the bone using metal hardware (osteosynthesis).
​However, in old age, bone tissue becomes fragile, accompanied by systemic inflammatory processes and multiple comorbidities. Consequently, post-operatively, the “bone-fixator” system may lose stability, the hardware may loosen, nonunion may occur, and secondary operations become necessary. Crucially, a simple and reliable tool to accurately assess this risk in advance was previously lacking.

​Essence of the invention
The scientists proposed a method to quantitatively calculate the risk of complications for each patient as early as the pre-operative stage. For this purpose, ten parameters are evaluated: the cortical index of the femur, time elapsed from injury to surgery, fracture classification, Charlson Comorbidity Index, injury mechanism, neutrophil-to-lymphocyte ratio, and markers of inflammation and bone turnover—IL-6, TNF-α, TGF-β, and the RANKL/OPG ratio.
​Each parameter is assigned a score from 1 to 3, the sum of which forms the Integral Prognostic Index (IPI). Based on the score, patients are assigned to one of three groups:
– IPI up to 14 points — low risk: standard osteosynthesis and bone-strengthening drug therapy (zoledronic acid, calcium, and vitamin D3);
– IPI 15–24 points — high risk: extended hardware designs, expanded locking mechanisms, and stabilization using specialized bone cement;
– IPI 25 points and above — critical risk: long structural designs, multiplanar fixation, extensive cement augmentation, and initiation of antiresorptive therapy prior to surgery.

​What are the benefits?
This method enables tailoring treatment specifically to each patient: low-risk patients avoid overly complex procedures, while high-risk patients receive pre-emptively reinforced fixation. This serves to reduce instances of secondary structural instability and impaired bone healing, prevent re-operations, enable faster patient mobilization, and shorten rehabilitation periods. For elderly individuals, this translates directly to preserved quality of life and independent mobility.

​Inventors
B.Z. Khamdamov, A.A. Ablakulov, V.R. Akramov, G.A. Ikhtiyarova, I.B. Khamdamov, S.S. Davlatov.

​Patent specifications
Patent: UZ IAP 8627.
Application: IAP 20260444, 02.06.2026.
Date of registration in the State Register of Inventions: 30.06.2026.
Official Bulletin: 31.07.2026, No. 7(303).
Patent validity: 20 years.

​This achievement serves as clear evidence that the scientific research conducted by university faculty directly supports clinical practice and the preservation of patient health.