Subject of the article

Authors

Ziyodullaev M.M.

Institution

Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan

Abstract

According to data from the World Health Organization, 3 million people die each year as a result of excessive alcohol consumption. This figure accounts for 5.3% of all deaths worldwide (WHO, 2020). Statistical data shows that in 2017, every second adult in the world consumed alcohol, indicating a risk of alcoholism for 2.6 billion people. Researchers note that over the past ten years, alcohol consumption has increased several times and is projected to continue growing in the future. Alcoholism can lead to both social and non-social health problems: cardiovascular diseases, cancers, gastrointestinal disorders, various pathological conditions of the nervous system, as well as numerous traffic accidents.

Key words

heart, ethanol, immunohistochemistry

Literature

1. Авантадилов Г. Г. Медицинская мор фометрия: Руководство //М.: Медицина. – 1990. – С. 384. достаточности и артериалъной гипертензии: дис. – Башкирский государственный медицинский университет, 2019.
2. Бабич И. И. Оперативные доступы при аутотрансплантации селезеночной ткани у детей //Сб. науч. трудов. Функционалъная морфология сердечнососудистой системы.–Ростов-на-Дону: Ростовский Ордена дружбы народов мед. инст. – 1988. – С. 18-19.
3. Багметова В. В. и др. Динамика потреб ления и формирования предпочтения алкоголя у самцов и самок крыс, подвергшихся хронической интоксикации 5%-м и 10%-м растворами этанола //Вестник Волгоградского государственного ме дицинского университета. – 2019. – №. 2 (70). – С. 17-22.
4. Быченкова М. А. Влияние густого экс тракта из травы первоцвета весеннего на течение эксперименталъной хронической сердечной недостаточности и артериалъной гипертензии: дис. – Башкирский государственный медицинский университет, 2019.
5. Жилин Р. А. Морфологические пара метры сердца диких кошачъих Приморского края : дис. – РА Жилин–Текст: непосредственный Улан-Удэ.–2017.–С. 25-28.
6. Кактурский Л. В., Пиголкин Ю. И., Горностаев Д. В. Судебно-медицинская экспер тиза скоропостижной смерти взрослых //Под ред. ЮИ Пиголкина. Судебная меди цина и судебно медицинская экспертиза: националъное руковод ство.–М.: ГЭОТАР–Медиа. – 2014. – С. 664-685.
7. Моисеев В.С. Алкоголная болезн. По ражение внутренних органов. – Москва : ГЭОТАР-Медиа, 2014 – С. 480.
8. Нуралиев Н.А., Эргашев В.А., Исмои лов Э.А. Экспериментал тадқиқотларда лабора тория ҳайвонлари билан ишлашнинг этик тамойиллари: шарҳ // Nazariy va klinik tibbiyot jurnali. – Тошкент, 2017. - №4. - 21-23 б
9. Сидорова П.И. Исползование лабора торных животных в токсикологическом экспе рименте: методические рекомендации. Под ред. Сидорова П.И. Архангелск. 2002. – C. 15.
10. Ягмуров О. Д. Гистогематический баръер сердца как морфологический критерий в судебно-медицинской диагностике алкоголъной кардиомиопатии //Судебно-медицинская экспер тиза. – 2015. – Т. 58. – №. 3. – С. 4-8.
11. Abbasi A. et al. Opioid receptors blockade modulates apoptosis in a rat model of cirrhotic car diomyopathy //Annals of Medical and Health Sci ences Research. – 2014. – Т. 4. – №. 3. – С. 404 409.
12. Adetunji Opeyemi Adebola1 et al. Ethanol and benzene induced toxicity in wistar rats: amelio rative effects of extra-virgin olive oil on haemato logical indices and spleen damage // European jour nal of pharmaceutical and medical research 2022. - № 9(8). – P. 523-531.
13. Afshar M. et al. Injured patients with very high blood alcohol concentrations //Injury. – 2016. – Vol. 47. – №. 1. – P. 83-88.
14. Barrio-Lopez M. T. et al. PREvention of recurrent arrhythmias with Mediterranean diet (PREDIMAR) study in patients with atrial fibrilla tion: Rationale,
15. Bukhari I. A. et al. Cardioprotective effect of olive oil against ischemia reperfusion-induced cardiac arrhythmia in isolated diabetic rat heart //Cureus. – 2020. – Vol. 12. – №. 2. – P. 36-45.
16. Chiva-Blanch G. et al. Effects of alcohol and polyphenols from beer on atherosclerotic bi omarkers in high cardiovascular risk men: a random ized feeding trial //Nutrition, Metabolism and Cardi ovascular Diseases. – 2015. – Vol. 25. – №. 1. – P. 36-45.
17. Covas M. I., de la Torre R., Fitó M. Virgin olive oil: A key food for cardiovascular risk protec tion //British Journal of Nutrition. – 2015. – Vol. 113. – №. 2. – P. 19-28.
18. D’Angelo C. et al. Wide biological role of hydroxytyrosol: possible therapeutic and preventive properties in cardiovascular diseases //Cells. – 2020. – Vol. 9. – №. 9. – P. 1932-1933.
19. Davis C. R. et al. A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized in tervention trial //The American journal of clinical nutrition. – 2017. – Vol. 105. – №. 6. – P. 1305 1313.
20. Dungdung A. et al. Clinical profile and prognostic factors of alcoholic cardiomyopathy in tribal and non-tribal population //Open Heart. – 2020. – Vol. 7. – №. 2. – P. 1334-1335.
21. Guasch-Ferré M. et al. Consumption of ol ive oil and risk of total and cause-specific mortality among US adults //Journal of the American College of Cardiology. – 2022. – Vol. 79. – №. 2. – P. 101 112.
22. Institute for Health Metrics and Evalua tion. (2019). GBD. //Archives of Public Health. – 2020. – Vol. 78. – P. 1-13.
23. Jimenez-Lopez C. et al. Bioactive com pounds and quality of extra virgin olive oil //Foods. – 2020. – Т. 9. – №. 8. – P. 1014-1015.
24. Klatsky A.L. Alcohol and cardiovascular diseases: where do we stand today? // Journal of In ternal Medicine - 2015. - № 3 (278). - P. 1365–2796.
25. Liang Y. et al. Chronic alcohol intake ex acerbates cardiac dysfunction after myocardial in farction //Alcohol and Alcoholism. – 2020. – Vol. 55. – №. 5. – P. 524-530.
26. Manthey J.J. et al. Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study //The Lancet. – 2019. – Vol. 393. – №. 10190. – P. 2493-2502.
27. Mohammadi S. et al. Study of the normal heart size in Northwest part of Iranian population: a cadaveric study //Journal of cardiovascular and tho racic research. – 2016. – Vol. 8. – №. 3. – P. 119 120.
28. Noce A., Marrone G., Urciuoli S., Di Dan iele F., Di Lauro M., Pietroboni Zaitseva A., Di Daniele N., Romani A. Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Manage ment of Chronic Kidney Disease Patients. Nutrients. 2021. – Vol. № 13(2). – P.581-582.
29. Rehm J. et al. The relationship between different dimensions of alcohol use and the burden of disease—an update //Addiction. – 2017. – Vol. 112. – №. 6. – P. 968-1001.
30. Rodrigues P. et al. Association between al cohol intake and cardiac remodeling //Journal of the American College of Cardiology. – 2018. – Vol. 72. – №. 13. – P. 1452-1462.
31. Salazar DM., Lуpez-Cortis I., Salazar Garcna DC. Olive oil: composition and health bene fits. Olive oil - sensory characteristics, composition and importance in human health // Nova Science Publishers Inc. - 2017. - № 1. – P.978-979.
32. Shaaban A. et al. Alcoholic cardiomyopa thy // StatPearls. – 2021. P.613-616.
33. Stanaway J. D., Afshin A., Gakidou E., Lim S. S., Abate D., Abate K. H., Murray C. J. L. Global, regional, and national comparative risk as sessment of 84 behavioural, environmental and oc cupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a sys tematic analysis for the Global Burden of Disease Study 2017 // The Lancet, - 2017. - № 39. – P. 392 393.