Subject of the article

Authors

Tilavov T.B. Khasanova D.A.

Institution

Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan

Abstract

Chronic kidney disease (CKD) is a progressive pathological condition often accompanied by dysfunction of the reproductive system, including testicular atrophy and impaired spermatogenesis. This study investigates the morphometric and morphological changes in the testes of male white albino rats with experimentally induced chronic kidney failure and evaluates the potential corrective effects of feru la moschata (sumbul root) extract. The study was conducted on 140 white albino rats divided into three age groups: 3, 6 and 9 months. Within each age group, animals were subdivided into control, CKD model, and treatment subgroups. Chronic kidney failure was induced using standard nephrotoxic agents. The treatment groups received sumbul root extract over a defined period. Testes were collected for gross anatomical, histo logical, and morphometric analyses. Parameters such as testis weight, capsule thickness, seminiferous tu bule diameter and area, and epitheliospermatogenic layer thickness were measured. The ratio of epithelial layer to lumen was also calculated. In untreated CKD rats, significant atrophic changes were observed in testicular tissues, including reduced seminiferous tubule diameter, thinning of the spermatogenic layer, and decreased organ weight. Administration of sumbul root extract in 3-month-old rats showed marked restora tion of testicular structure and morphometric indices close to control values. The therapeutic effect was moderate in 6-month-old rats and limited in 9-month-old animals, reflecting an age-dependent regenerative response. Sumbul root extract demonstrates age-dependent therapeutic potential in reversing CKD-induced testicular damage. Early intervention yields more pronounced morphofunctional recovery, suggesting its promise as a phytotherapeutic agent in CKD-related gonadal dysfunction.

Key words

Chronic kidney disease, testicular morphology, morphometry, ferula mochata, sumbul root extract, seminiferous tubules, spermatogenesis, rat model, age-dependent regeneration, phytotherapy.

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