Subject of the article

Authors

Bakhronov B.B., Navruzov R.R.

Institution

Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan

Abstract

This review article examines modern approaches to the use of biostimulators for correcting morphofunctional disorders of the esophageal mucosa in rats exposed to the toxic effects of carbon monox ide. The mechanisms of action of various groups of biostimulators (of plant, tissue, and synthetic origin) are analyzed, including their influence on epithelial regeneration, angiogenesis, antioxidant defense, and modu lation of inflammatory processes. Particular attention is given to experimental data on the impact of bi ostimulators on the restoration of the morphology and function of the esophageal mucosa, including accel erated epithelialization, activation of cellular proliferation, and reduction of pro-inflammatory mediator ex pression. The presented data highlight the promising potential of biostimulators in the complex therapy of toxic esophageal injuries, which may contribute to the development of new methods for prevention and treatment of this pathology.

Key words

biostimulators; carbon monoxide; regeneration; rats; angiogenesis; antioxidant activity; inflammation.

Literature

1. Всемирная организация здравоохране ния. Загрязнение воздуха и здоровье. — 2022. URL: https://www.who.int/ (дата обращения: 12.05.2025).
2. Попов В.И. Токсикология загрязнителей атмосферного воздуха. — М.: Медицина, 2019. — 272 с.
3. Степанов А.В., Гончаров А.А. Воздей ствие угарного газа на организм человека // Вестник экологической медицины. — 2021. — №2. — С. 45–50.
4. Kales S.N., Christiani D.C. Acute chemical emergencies. Carbon monoxide poisoning // N. Engl. J. Med. — 2002. — Vol. 347. — P. 1054 1055.
5. Центр Гидрометеорологической службы Республики Узбекистан (Узгидромет). Ежегод ный экологический бюллетень за 2023 год. — Ташкент, 2024.
6. Brown G.C., Cooper C.E. Nanomolar con centrations of nitric oxide reversibly inhibit synapto somal respiration by competing with oxygen at cyto chrome oxidase. FEBS Lett. 1994;356(2–3):295 298.
7. Weaver L.K. Carbon monoxide poisoning. N Engl J Med. 2009;360(12):1217–1225.
8. Thom S.R., Bhopale V.M., Fisher D., Zhang J. et al. Delayed neuropathology after carbon monoxide poisoning is immune-mediated. Proc Natl Acad Sci USA. 2004;101(37):13660–13665.
9. Ryter S.W., Otterbein L.E. Carbon monox ide in biology and medicine. Bioessays. 2004;26(3):270–280.
10. Zhou D., Pan Q., Xin F. et al. Carbon monoxide-induced intestinal microbiota dysbiosis aggravates gut barrier dysfunction. Front Cell Infect Microbiol. 2021;11:630189.
11. Kocyigit A., Guler E.M., Dikilitas M., Ce lik H. Oxidative stress and antioxidant status in pa tients with carbon monoxide poisoning. Redox Rep. 2005;10(2):77–82.
12. Benignus V.A., Ball R.T., Faulkner K.L. Acute and chronic effects of carbon monoxide expo sure on the respiratory system in rats. Toxicol Appl Pharmacol. 2000;163(1):16–23.
13. Abboud K.A., Hume S., Shehadeh H. Ef fects of carbon monoxide on gastrointestinal tract tissues in rats. J Appl Toxicol. 2011;31(4):357–364.
14. Yandim M.K., Yılmaz H., Karaca M. et al. Effects of long-term carbon monoxide exposure on gastric and esophageal mucosa. J Toxicol Envi ron Health A. 2015;78(13):809–818.
15. Derakhshan A., Sadeghian S. Chronic ex posure to low levels of carbon monoxide: morpho logic changes in gastric and esophageal epithelium. J Exp Clin Toxicol. 2020;41(3):265–275.
16. Aydin M.D. et al. CO-induced neuromus cular disruption in esophageal peristalsis. Toxicol Ind Health. 2019;35(4):265–273.
17. Zhang L. et al. Effect of carbon monoxide on esophageal motility in rats. J Gastrointest Motil. 2018;24(3):211–218.
18. Liu W. et al. LES dysfunction induced by CO inhalation. Clin Exp Gastroenterol. 2017;10:253–259.
19. Nam K.H. et al. Manometric changes in patients after CO exposure. Dis Esophagus. 2020;33(4):doaa002.
20. Choi Y., Kim S.J. Tight junction disrup tion in the esophagus after CO inhalation. Toxicol Lett. 2017;280:42–49.
21. Zhang J. et al. LPS penetration into esoph ageal wall under CO intoxication. Exp Toxicol Pathol. 2017;69(8):579–586.
22. Kim H.S., Woo J.K. Barrier dysfunction and inflammation in CO-induced esophagitis. World J Gastroenterol. 2020;26(14):1673–1681.
23. Lee S.Y. et al. Histopathologic signs of chronic esophagitis in CO-exposed rats. J Vet Sci. 2020;21(3):e36.
24. Park J.H. et al. Expression of adhesion molecules in chronic CO toxicity. Cell Immunol. 2019;335:30–38.
25. Choi M. et al. GI symptoms and motility disorders in CO-poisoned patients. Korean J Gastro enterol. 2021;77(1):42–48.
26. Wald N.J. et al. Carbon monoxide expo sure in fire victims and GI tract impact. Thorax. 1981;36(5):366–369.
27. Ahn J.H. et al. Recovery timeline of esophageal damage after CO exposure. Toxicol Appl Pharmacol. 2022;437:115889.
28. Josias H.A., Nogueira F.J., et al. Aloe vera as a therapeutic agent in esophageal injury: experi mental evidence. J Ethnopharmacol. 2021;265:113268.
29. Kim J.H., Yi Y.S., Kim M.Y., Cho J.Y. Role of ginseng in inflammation and repair. J Gin seng Res. 2017;41(4):435–443.
30. Kim J.H., Yi Y.S., Kim M.Y., Cho J.Y. Role of ginseng in inflammation and repair. J Gin seng Res. 2017;41(4):435–443.
31. Belyaeva I.A., Mikhailov V.V. Experi mental use of vitreous body extract in tissue repair. Bull Exp Biol Med. 2019;167(5):621–625.
32. Malkova N.I. Morphometric evaluation of esophageal healing with tissue biostimulators. Exp Pathol. 2021;18(2):121–126.
33. Zhu J., Wu C. Role of VEGF expression in esophageal mucosa repair under biostimulant ac tion. J Med Biochem. 2020;39(4):447–453.
34. Tursunov M.R. Antioxidant profile resto ration with plant-based biostimulants. Oxid Med Cell Longev. 2021;2021:8876592.
35. Smirnova E.S., Rudenko A.A. Regulation of cytokine profile in esophageal inflammation by placental extracts. Cytol Histol. 2019;60(1):33–38.
36. Li F., Li H. Molecular mechanisms of tis sue regeneration with solcoseryl: activation of MAPK and PI3K pathways. Toxicol Lett. 2022;358:16–22.
37. Artemyev D.V., Ivanov A.S. Immunocyto chemical profile of esophageal mucosa after treat ment with tissue biostimulants. Exp Clin Gastroen terol. 2023;2:41–46.
38. Iskandarov M.F. Comparative efficacy of biogenic stimulants in esophageal tissue repair post CO exposure. Uzbek Med J. 2023;3(2):71–78.
39. Khalikov R.B. Evaluation of hepatotoxici ty in high-dose actovegin therapy in rats. Pharmacol Rep. 2021;73(4):892–899.
40. Yakubov T.S. Immunohistochemical markers of esophageal recovery: comparative study. Histochem Cell Biol. 2022;158(3):313–320.