KORONAVIRUS INFEKTSIYASINING KLINIK KECHISHIGA ORGANIZM IMMUNOBIOLOGIK TARKIBIY QISMLARINING TA’SIRI

Фундаментал ва клиник тиббиёт ахборотномаси, 2022 №5

Maqola mavzusi

KORONAVIRUS INFEKTSIYASINING KLINIK KECHISHIGA ORGANIZM IMMUNOBIOLOGIK TARKIBIY QISMLARINING TA’SIRI (136-148)

Mualliflar

G‘iyozova M.M.

Muassasa

Buхоrо davlat tibbiyot instituti

Annotatsiya

Bugungi kunga qadar tibbiyotning koronavirus infeksiyasidan zarar ko‘rmaydigan birorta tarmog‘i qolmadi, ya’ni SARS-Co I-2 infeksiyasidan zarar ko‘rmagan va patologiyasi bo‘lmagan organlar va tizimlar yo‘q. L shubhasiz. Virusli infektsiyalar bilan, tibbiyot jamiyati tajribasi ilgari ko'rsatganidek, virusologlar va immunologlar shug'ullangan, ammo koronavirus infektsiyasi bilan SARS-CoV-2 tanaga shunchalik chuqur va har tomonlama kirib bordiki, tegishli mutaxassislar yordam bera olmadilar. ushbu yo'nalishda ilmiy tadqiqotlarni o'rganish va olib borish masalalari. Koronavirus infeksiyasi va uning asoratlarini davolashda organizmning immunobiologiyasi jarayonini o‘rganish muhim ahamiyatga ega. Immunobiologiya bo'yicha bilimlarga bo'lgan ehtiyoj virusli, xususan, koronavirus infektsiyasini tashxislash va davolashda yangi tibbiy usullar va texnologiyalarni joriy etish imkoniyati bilan ham belgilanadi. Angiotensin-konverting ferment-2 (ACE2) va TMPRSS2 ning sirt retseptorlarini ifodalovchi SARS-Co\ '-2 infektsiyali hujayralar, virusning faol replikatsiyasini va chiqarilishini rivojlantiradi, piroptoz paydo bo'ladi - hujayralarning molekulyar tuzilishiga zarar, shu jumladan .1 TP, nuklein kislotalar va ASC oligomerlari. Ular qo'shni epitelial hujayralar, endotelial hujayralar va alveolyar makrofaglar tomonidan tan olinadi, bu yallig'lanishga qarshi sitokinlar va kimyokinlar (jumladan, IL-6, IP-10, makrofag yallig'lanish oqsili la (MI Pl a), MIPlp va MCP1) hosil bo'lishiga olib keladi. Ular monotsitlar, makrofaglar va T hujayralarini infektsiya o'chog'iga jalb qilib, keyingi yallig'lanishni rag'batlantiradilar (T hujayralari tomonidan ishlab chiqarilgan IF.\f biriktirilishi bilan), yallig'lanishga qarshi teskari aloqa zanjiri hosil bo'ladi, immun hujayralar to'planadi, yallig'lanishga qarshi. sitokinlar sitokin bo'ronining rivojlanishi bilan ishlab chiqariladi, bu ko'plab organlarning shikastlanishiga olib keladi. Bundan tashqari, SARS-CoV-2 ning faolligi antikorga bog'liq kuchayish (ADE) orqali kuchayadi, bu organlarning, shu jumladan asab tizimi va og'iz bo'shlig'ining shikastlanishini yanada kuchaytiradi. Koronavirus infektsiyasining alomatlari va asoratlarini davolashda immunitetning hujayra, so‘ngra tizimli darajada o‘zgarishini hisobga olish, shu orqali infektsiyalangan organizmni davolashda shart-sharoitlar va ma’lum terapiyani yaratish hamda asoratlar rivojlanishining oldini olish muhim ahamiyatga ega. va COVID-19 dan o'lim.

Kalit so'zlar

immunobiologik komponentlar, koronavirus infeksiyasining klinik kechishi, angiotenzinga aylantiruvchi ferment, ko'p organlar.

Adabiyotlar

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