Maqola mavzusi

Mualliflar

Sadikova A.M.

Muassasa

Tashkent State Medical University, Tashkent, Uzbekistan

Annotatsiya

Juvenile rheumatoid arthritis (JRA) represents a chronic autoimmune pathology characterized by persistent synovial inflammation, progressive joint destruction, and systemic immune dysregulation. The disease arises from a multifactorial interplay of genetic predisposition, environmental triggers, and aberrant cytokine signaling that to gether drive chronic inflammation. In this study, the serum levels of key inflammatory mediators — IL-8, IL-17A, and IFN-γ — were examined in 106 children with JRA aged 3 to 18 years, alongside a control group of 40 healthy individuals. The analysis demonstrated a marked elevation of IL-8 and IL-17A concentrations, particularly among patients with the seropositive form of JRA, most prominently expressed in adolescents aged 15–18 years. Conversely, a significant suppression of IFN-γ production was recorded in both disease variants, with the most profound deficit observed in seropositive patients, indicating impaired Th1-type immune regulation. These immunological alterations emphasize the dominance of proinflammatory cytokine activity and the attenuation of protective immune responses in JRA. Collectively, the findings underscore the diagnostic and therapeutic potential of cytokine profiling as a biomarker-guided approach for assessing disease activity and tailoring personalized treatment strategies

Kalit so'zlar

JRA, IL-8, IL-17A, INFy, seronegative, seropositive

Adabiyotlar