Maqola mavzusi

Mualliflar

Мурадова Р.Р.

Muassasa

Самарқанд давлат тиббиёт университети, Самарқанд ш., Ўзбекистон

Annotatsiya

Мақола руҳий саломатлик ва сурункали касалликларда рақамли терапевтик воситалар (DTx) нинг ролини кўриб чиқади, клиник фармакологияга интеграция қилиш ва фармакодинамик хусусиятларига еътибор қаратади. У асосий жиҳатларни, жумладан, машина ўрганиш орқали симптомларни башорат қилиш, DTx комбинацияларини топиш ва клиник амалиётга интеграция қилишни ўрганади. PubMed, Nature ва ScienceDirect дан сўнгги тадқиқотлар (2020–2025) асосида, депрессия, хавотир, диабет ва гипертония каби касалликларда DTx моделларининг натижалари тақдим этилади. Моделлар интерпретацияси ва ахлоқий масалалар каби қийинчиликлар, шунингдек, янги DTx ни кашф этишда истиқболлар муҳокама қилинади. Тадқиқот глобал саломатлик таҳдидини камайтиришда DTx нинг потенциалини таъкидлайди. https://doi.org/10.5281/zenodo.18161264  

Kalit so'zlar

рақамли терапевтик воситалар, руҳий саломатлик, сурункали касалликлар, клиник фармако-логия, фармакодинамика, машина ўрганиш.

Adabiyotlar

1. Espie, C. A., Emsley, R., Kyle, S. D., Gordon, C., Drake, C. L., Siriwardena, A. N., Cape, J., Ong, J. C., Sheaves, B., Foster, R., Freeman, D., Costa, B., Calitri, R., Day, E., Eastaugh, J., Larkham, P., Nickson, S., Spanakis, P., Tate, A., & Luik, A. I. (2019). Effect of digital cognitive behavioral therapy for insomnia on health, psychological well-being, and sleep-related quality of life: A randomized clinical trial. JAMA Psychiatry, 76(1), 21–30. https://doi.org/10.1001/jamapsychiatry.2018.2745
2. Hong, J. S., Wasden, C., & Han, D. H. (2021). Introduction of digital therapeutics. Computer methods and programs in biomedicine, 209, 106319. https://doi.org/10.1016/j.cmpb.2021.106319
3. Garbett K, Craddock N, Haywood S, Nasution K, White P, Saraswati L, Medise B, Girl Effect , Percolate Galactic , Diedrichs P, Williamson H. A Novel, Scalable Social Media–Based Intervention (“Warna-Warni Waktu”) to Reduce Body Dissatisfaction Among Young Indonesian Women: Protocol for a Parallel Randomized Controlled Trial. JMIR Res Protoc 2022;11(1):e33596 URL: https://www.researchprotocols.org/2022/1/e33596 DOI: 10.2196/33596
4. Brezing, C. A., & Levin, F. R. (2022). Applications of technology in the assessment and treatment of cannabis use disorder. Frontiers in Psychiatry, 13, Article 1035345. https://doi.org/10.3389/fpsyt.2022.1035345
5. Yoon, H., & Baek, H. J. (2022). External auditory stimulation as a non-pharmacological sleep aid. Sensors, 22(3), 1264. https://doi.org/10.3390/s22031264
6. Porosnicu Rodriguez, K. A., O'Brien, J. B., & Turner, J. A. (2023). Digital therapeutics for insomnia: A systematic review and network meta-analysis. Sleep Medicine Reviews, 68, 101745. https://doi.org/10.1016/j.smrv.2023.101745
7. Quah, S. R. (Ed.). (2017). Title of the book. Academic Press. https://doi.org/10.1016/B978-0-12-803708-9.00001-9
8. Hadjiat, Y., & Marchand, S. (2022). Virtual Reality and the Mediation of Acute and Chronic Pain in Adult and Pediatric Populations: Research Developments. Frontiers in pain research (Lausanne, Switzerland), 3, 840921. https://doi.org/10.3389/fpain.2022.840921
9. Adam, M., Wessel, M. & Benlian, A. AI-based chatbots in customer service and their effects on user compliance. Electron Markets 31, 427–445 (2021). https://doi.org/10.1007/s12525-020-00414-7
10. Abbadessa, G., Brigo, F., Clerico, M. et al. Digital therapeutics in neurology. J Neurol 269, 1209–1224 (2022). https://doi.org/10.1007/s00415-021-10608-4
11. Greywoode, R., & Szigethy, E. (2022). Behavioral digital therapeutics in gastrointestinal conditions: Where are we now and where should we go? Gastroenterology Clinics of North America, 51(4), 741–752. https://doi.org/10.1016/j.gtc.2022.07.011
12. Hasan, A., Panja, P., & Maheshwari, B. (2023). Digital therapeutics for irritable bowel syndrome: A systematic review and meta-analysis. Neurogastroenterology & Motility, 35(4), e14528. https://doi.org/10.1111/nmo.14528
13. Zhang, Y., Li, L., Zhang, Y., Zhao, J., Jiang, N., Gao, Y., Li, X., Sun, Q., Liu, J., Liang, W., & Yang, M. (2022). Effect of a smartphone-based intervention on secondary prevention medication prescriptions after coronary artery bypass graft surgery: The SMARTGRAFT randomized clinical trial. American Heart Journal, 243, 34–42. https://doi.org/10.1016/j.ahj.2021.08.010
14. Kario, K., Nomura, A., Harada, N., Okura, A., Nakagawa, K., Tanigawa, T., & Hida, E. (2021). Efficacy of a digital therapeutics system in the management of essential hypertension: the HERB-DH1 pivotal trial. European heart journal, 42(40), 4111–4122. https://doi.org/10.1093/eurheartj/ehab559
15. Ellahham, S. (2020). Artificial intelligence: The future for diabetes care. The American Journal of Medicine, 133(8), 895–900. https://doi.org/10.1016/j.amjmed.2020.03.033
16. Aapro, M., Bossi, P., Dasari, A., Fallowfield, L., Gascón, P., Geller, M., Jordan, K., Mucci, A., Schulz, V., & Valentini, G. (2020). Digital health for optimal supportive care in oncology: Benefits, limits, and future perspectives. Supportive Care in Cancer, 28(10), 4589–4612. https://doi.org/10.1007/s00520-020-05539-1
17. Patel, N. A., & Butte, A. J. (2020). Characteristics and challenges of the clinical pipeline of digital therapeutics. NPJ Digital Medicine, 3(1), 159. https://doi.org/10.1038/s41746-020-00370-8
18. Wang, C., Lee, C., & Shin, H. (2023). Digital therapeutics from bench to bedside. NPJ Digital Medicine, 6(1), 38. https://doi.org/10.1038/s41746-023-00777-z
19. Benning, N. H., Knaup, P., & Haux, R. (2024). Performance-based reimbursement for digital therapeutics in Germany: A misconceptualized opportunity. NPJ Digital Medicine, 7(1), 1–9. https://doi.org/10.1038/s41746-024-01050-7
20. Amirabdolahian, F., & Brusseau, T. A. (2025). Digital wellness programs in the workplace: A meta-review of the literature. Journal of Occupational Health Psychology, 30(1), 45–67. https://doi.org/10.1037/ocp0000367
21. Huh, K. Y., Oh, J., Lee, S., & Yu, K. S. (2022). Clinical evaluation of digital therapeutics: Present and future. Healthcare Informatics Research, 28(3), 188–197. https://doi.org/10.4258/hir.2022.28.3.188
22. Mishra, V., Vyas, S., & Doraiswamy, P. M. (2024). Assessment of India's Ayushman Bharat Digital Mission. The Lancet Digital Health, 6(4), e245–e256. https://doi.org/10.1016/S2589-7500(24)00034-5
23. Fuerstenau, B., Auschra, C., Klein, R., & Gersch, M. (2023). Digital therapeutics (DTx): A scoping review of definitions, models, and research areas. Digital Health, 9, 20552076231179062. https://doi.org/10.1177/20552076231179062
24. Santomauro, D. F., Herrera, A. M. M., Shadid, J., Zheng, P., Ashbaugh, C., Pigott, D. M., Abbafati, C., Adolph, C., Amlag, J. O., Aravkin, A. Y., Bang-Jensen, B. L., Bertolacci, G. J., Bloom, S. S., Castellano, R., Castro, E., Chakrabarti, S., Chattopadhyay, J., Cogen, R. M., Collins, J. K., ... Ferrari, A. J. (2021). Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. The Lancet, 398(10312), 1700–1712. https://doi.org/10.1016/S0140-6736(21)02143-7
25. Carter, H., Araya, R., Anjur, K., Deng, D., & Naslund, J. A. (2021). The emergence of digital mental health in low-income and middle-income countries: A review of recent advances and implications for the treatment and prevention of mental disorders. EClinicalMedicine, 41, 101136. https://doi.org/10.1016/j.eclinm.2021.101136
26. Biskupiak, Z., Ha, V. V., Rohaj, A., & Bulaj, G. (2024). Digital therapeutics for improving effectiveness of pharmaceutical drugs and biological products: Preclinical and clinical studies supporting development of drug + digital combination therapies for chronic diseases. Journal of Clinical Medicine, 13(2), 403. https://doi.org/10.3390/jcm13020403
27. Clevert, D.-A., Wand, M., Malinovská, K., Schmidhuber, J., & Tetko, I. V. (Eds.). (2025). AI in drug discovery: Proceedings of the First International Workshop, AIDD 2024, held in conjunction with ICANN 2024, Lugano, Switzerland, September 19, 2024. Lecture Notes in Computer Science (Vol. 14894).
28. Colloud, S., Metcalfe, T., Askin, S., Belachew, S., Ammann, J., Bos, E., Kilchenmann, T., Strijbos, P., Eggenspieler, D., Servais, L., Garay, C., Konstantakopoulos, A., Ritzhaupt, A., Vetter, T., Vincenzi, C., & Cerreta, F. (2023). Evolving regulatory perspectives on digital health technologies for medicinal product development. NPJ digital medicine, 6(1), 56. https://doi.org/10.1038/s41746-023-00790-2
29. Yoo, Joo & Jeong, Harim & Chung, Tai-Myoung. (2023). Cutting-Edge Technologies for Digital Therapeutics: A Review and Architecture Proposals for Future Directions. Applied Sciences. 13. 6929. 10.3390/app13126929.