Bulletin of fundamental and clinic medicine, 2022 №4

Subject of the article



Kayumova Dilrabo Tolmasovna, Nabieva Rano Muzaffar qizi


Tashkent Medical Academy, Uzbekistan, Tashkent


The problem of fetal growth restriction and development is quite common and is recorded at every 10th pregnancy. About 40% of fetuses with weight and / or body length below the 10th percentile are healthy children, and the decrease in anthropometric indicators can be attributed to their constitutional features. In 20% of cases, the cause of fetal growth restriction (FGR) is a genetic or infectious pathology (deletion of the short arm of the 4th chromosome, the long arm of chromosome 13, trisomy for the 13th, 18th, 21st pairs, hereditary metabolic diseases, herpes and cytomegalovirus infection). Identifying the causes and timing of fetal growth impairment is more significant for predicting immediate and long-term consequences than the proportion of a child at birth. The link between the placenta and fetal growth is more significant than previously thought. Studying the most significant risk factors, diagnostic features are relevant and created the opportunity prevention of intrauterine growth retardation.

Key words

fetus, intrauterine development delays, metabolism, childbirth


  1. Белоусова Т.В., Андрюшина И.В. Задержка внутриутробного развития и ее влияние на состояние здоровья детей в последующие периоды жизни. Возможности нутритивной коррекции // Вопросы современной педиатрии, 2015; 14 (1): 23–30.
  2. Ковтун О.П., Цывьян П.Б. Преждевременное рождение и программирование заболеваний. Вклад интенсивной терапии // Вопросы современной педиатрии, 2014; 13 (5): 26–30.
  3. Aucott S.W., Donohue P.K., Northington F.J. Increased morbidity in severe early intrauterine growth restriction // J. Perinatol., 2004; 24: 435−440.
  4. Barker D.J., Hanson M.A. Altered regional blood flow in the fetus: the origins of cardiovascular disease? Acta Paediatr., 2004; 93: 1559−1560.
  5. Bartels D.B., Schwab F., Geffers C. et al. Nosocomial infection in small for gestational age newborns with birth weight.
  6. Battaglia F.C., Lubchenko L.O. A practical classification of newborn infants by weight and gestational age // J. Pediatr. 1967; 71: 159–163.
  7. Bernstein I.M., Horbar J.D., Badger G.J. et al. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network // Am. J. Obstet. Gynecol., 2000; 182: 198−206.
  8. Bertino E., Di Battista E., Bossi A. et al. Fetal growth velocity: kinetic, clinical, and biological aspects. Arch Dis. Childhood, 1996; 74: F10−15.
  9. Bertino E., Milani S., Fabris C., De Curtis M. Neonatal anthropometric charts: what they are, what they are not. Arch Dis. Child Fetal Neonatal. Ed., 2007; 92: 7−10.
  10. Bertino E., Coscia A., Boni L. et al. Weight growth velocity of very low birth weight infants: role of gender, gestational age and major morbidities. Early Hum. Dev., 2009; 85: 339−347.
  11. Buonocore G. et al. (eds.) Neonatology. A Practical Approach to Neonatal Diseases. Springer-Verlag, Italia, 2012, 1376 p.
  12. Cameron N. Measuring techniques and instruments. In: Nicoletti I., Benso L., Gilli G. (eds.) Physiological and pathological auxology. Edizioni Centro Studi Auxologici, Firenze, 2004, pp. 117−159.
  13. Casey P.H. Growth of Low Birth Weight Preterm Children. Sem. Perinatol., 2008; 32: 20−27.
  14. Chauhan S.P., Lavery J.A., Ananth C.V. Small for gestational age: reassessment of birthweight percentile linked with neonatal mortality in the United States // American Journal of Obstetrics & Gynecology Suppl., 2016 January; 321.
  15. Clayton P.E., Cianfarani S., Czernichow P. et al. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society // J. Clin. Endocrinol. Metab., 2007; 92: 804−810.
  16. Dhaliwal C.A., Fleck B.W., Wright E. et al. Retinopathy of premature in small- for gestational age infants compared with those of appropriate size for gestational age. Arch Dis. Child Fetal Neonatal. Ed., 2009; 94: F193−195.
  17. Dorling J., Kempley S., Leaf A. Feeding growth restricted preterm infants with abnormal antenatal Doppler results. Arch Dis Child Fetal Neonatal. Ed., 2005; 90: F359−363.
  18. Gardosi J. Customized fetal growth standards: rationale and clinical application. Semin. Perinatol., 2004; 28: 33–40.
  19. Halliday H.L. Neonatal management and long-term sequelae. Best Pract. Res. Clin. Obstet. Gynaecol., 2009; 23: 871–880.
  20. Hendrix N., Berghella V. Non-placental causes of intrauterine growth restriction. Semin. Perinatol., 2008; 32: 161–165.
  21. Hernаndez M.I., Mericq V. Impact of being born small for gestational age on onset and progression of puberty. Best Pract. Res. Clin. Endocrinol. Metab., 2008; 22: 463−476.
  22. Kinsella J.P., Greenough A., Abman S.H. Bronchopulmonary dysplasia. Lancet, 2006; 367: 1421−1431.
  23. Koleganova N., Piecha G., Ritz E. Prenatal causes of kidney disease. Blood Purif., 2009; 27: 48−52.
  24. Lal M.K., Manktelow B.N., Draper E.S., Field D.J. Chronic lung disease of prematurity and intrauterine growth retardation: a population-based study // Pediatrics 2003; 111: 483−487.
  25. Lestari H., As'ad S., Yusuf I., Umboh1 A., Febriani A.D.B. Developmental performance in small for gestational age children with and without catch-up growth. Paediatr. Indones., 2015; 55: 199–202.
  26. Lundgren E.M., Tuvemo T. Effects of being born small for gestational age on long-term intellectual performance. Best Pract. Res. Clin. Endocrinol. Metab., 2008; 22: 477−488.
  27. Main K.M., Jensen R.B., Asklund C. et al. Low birth weight and male reproductive function. Horm. Res., 2006; 65: 116−122.
  28. Marconi A.M., Ronzoni S., Bozzetti P. et al. Comparison of fetal and neonatal growth curves in detecting growth restriction. Obstet Gynecol., 2008; 112: 1227–1234.
  29. McIntire D.D., Bloom S.L., Casey B.M. et al. Birth weight in relation to morbidity and mortality among newborn infants // N. Engl. J. Med., 1999; 340: 1234−1238.
  30. McMillen I., Adams M., Ross J. et al. Fetal growth restriction: adaptation and consequences // Reproduction, 2001; 122: 195–204.
  31. Mendez-Figueroa1 H., Chauhan1 S.P., Truongl V.T.T, Pedroza C. Morbidity and mortality with small for gestational age: secondary analysis of nine MFMU network studies // American Journal of Obstetrics & Gynecology, suppl. to 2016 January: 320.
  32. Mitsiakos G., Papaioannou G., Papadakis E. et al. Haemostatic profile of full-term, healthy, small for gestational age neonates. Thromb Res., 2009; 124: 288−291.
  33. Murdoch E.M., Sinha A.K., Shanmugalingam S.T. et al. Doppler flow velocimetry in the superior mesenteric artery on the first day of life in preterm infants and the risk of neonatal necrotizing enterocolitis // Pediatrics, 2006; 118: 1999−2003.
  34. Pallotto E.K., Kilbride H.W. Perinatal outcome and later implications of intrauterine growth restriction // Clin. Obstet Gynecol., 2006; 49: 257−269.
  35. Pallotto E.K., Woelnerhanssen B., Putt M. et al Incidence and risk factors for prolonged hypoglycemia in small for gestational age infants. Abstract. Society for Pediatric and Perinatal Epidemiology, 2004.
  36. Pulver L.S., Guest-Warnick G., Stoddard G.J. et al. Weight for gestational age affects the mortality of late preterm infants // Pediatrics, 2009; 123: e1072−1077.
  37. Rai S., Kaur S., Hamid A. Changes in serum calcium and serum glucose levels in asphyxiated SGA // Journal of Evolution of Medical and Dental Sciences, 2015; 4 (77): 13411–13416.
  38. Regev R.H., Lusky A., Dolfin T. et al. Excess mortality and morbidity among small-for-gestational-age premature infants: a population-based study // J. Pediatr. 2003; 143:186−191.
  39. Riskin-Mashiah S., Riskin A., Bader D., Kugelman A., Boyko V., Lerner-Geva L., Reichman B. Antenatal corticosteroid treatment in singleton, small-for-gestational-age infants born at 24–31 weeks' gestation: a population-based study // An International Journal of Obstetrics & Gynaecology, Nov 2015 DOI: 10.1111/1471-0528.13723.
  40. Rosenberg A. The IUGR Newborn. Semin. Perinatol., 2008; 32: 219−224.
  41. Saenger P., Czernichow P., Hughes I., Reiter E.O. Small for gestational age: short stature and beyond. Endocr. Rev., 2007; 28: 219−251.
  42. Sarkar S., Rosenkrantz T.S. Neonatal polycythemia and hyperviscosity. Semin. Fetal Neonatal. Med., 2008; 13: 248−255.
  43. Shand A.W., Hornbuckle J., Nathan E. et al. Small for gestational age preterm infants and relationship of abnormal umbilical artery Doppler blood flow to perinatal mortality and neurodevelopmental outcomes // Aust N Z J Obstet Gynaecol., 2009; 49: 52−58.
  44. Singer D.B., Sung C.J., Wigglesworth J.S. Fetal growth and maturation with standards for body and organ development. In E. Bertino et al. Wigglesworth J.S., Singer D.B. (eds.) Textbook of fetal and perinatal pathology. Blackwell Scientific Publications, London, 1991, pp. 11−47.
  45. Smith L.E. IGF-1 and retinopathy of prematurity in the preterm infant. Biol. Neonate, 2005; 88: 237– 244.
  46. Todros T., Ferrazzi E., Groli C. et al Fitting growth curves to head and abdomen measurements of the fetus: a multicentric study // J. Clin. Ultrasound, 1987; 15: 95–105.
  47. Vashevnik S., Walker S., Permezel M. Stillbirths and neonatal deaths in appropriate, small and large birthweight for gestational age fetuses // Aust N Z J Obstet Gynaecol., 2007; 47: 302−306.
  48. Vrachnis N., Botsis D., Iliodromiti Z. The fetus that is small for gestational age. Ann. NY Acad. Sci., 2006; 1092: 304−309.