Bulletin of fundamental and clinic medicine, 2022 №5
Subject of the article
PATHOMORPHOLOGICAL CHARACTERISTICS OF THE LIVER IN THE TRANSITION OF FIBROSIS TO CIRRHOSIS (300-305)
Authors
Lebedeva E.I. , Shchastniy A.T. , Babenka A.S.
Institution
Vitebsk State Medical University ,Belarussian State Medical University
Abstract
Currently, the methods of treating liver diseases in which fibrosis is a key pathogenetic factor, still remain an urgent problem of hepatology. Aim of this work is the study of structural changes and phenotypic profile of rat cells (Wistar line) with nodal parenchyma. Based on the results obtained, it is possible to set the point of transition of fibrosis to cirrhosis as an independent separate stage of fibrogenesis and, as part of these studies, this happened on the 11th week (F5), and the process itself-from the 9th to the 13th week (F4/F5-F6). During this period, with the growth of fibrous tissue and nodal restructuring of the liver parenchyma, the progression of dystrophic processes and an increase in the zones of necrosis and necrobiosis of hepatocytes did not note. At the F5 stage, the number of α-SMA+-and FAP+-cells, as the main producers of pathological connective tissue, has not changed. During the F5-F6 period, there were no differences in the number of various populations of macrophages expressing markers of CD68, CD206, CX3CR1.
Key words
rats, liver fibrosis and cirrhosis, morphology, immunogystochemistry.
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