Subject of the article

Authors

Makhmatmuradova N.N.

Institution

Samarkand State Medical University

Abstract

With nonspecific interstitial pneumonia, violations of the immunocompetent cells of the peripheral bloodstream occur in the form of a change in the concentration of serum cytokines - IL-1β, IL-17A. They determine the production of acute phase proteins, fibrinogen, the level of leukocytosis and the level of SRE. The relationship between changes in the concentration of interleukins and the severity of the pathology was established. The foregoing confirms the undoubted participation of interleukins at the beginning and in the process of the formation of the pathological process, especially in patients with moderate and severe course, and to a lesser extent in patients with mild ones.

Key words

nonspecific interstitial pneumonia, blood plazma, interleukins.

Literature

1. Тарасова И.В. «Дирижеры» межклеточных взаимодействий - цитокины // Аллергология и иммунология в педиатрии. - 2011. - № 1 (24). -С. 36-40.
2. Щербак В.В., Фомочкина И.И., Кубышкин А.В. Изменения неспецифических протеиназ и их ингибиторов при коррекции течения экспериментального воспаления легких антибиотиками, ингибиторами протеиназ и антиоксидантами //Таврический медико-биологический вестник. – 2012. – Т. 15., № 3-1. – С. 383-386.
3. Boxio R., Wartelle J., Nawrocki-Raby B., Lagrange B., Malleret L., Hirche T., Taggart C., Pacheco Y., Devouassoux G., Bentaher A. Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium.// Respir Res. - 2016 Oct. – P.117-129.
4. De Brouwer B., Drent M., van den Ouweland J.M.W., Wijnen P.A., van Moorsel C.H.M., Bekers O., Grutters J.C., White E.S., Janssen R. Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis. // Respir Res. - 2018 Mar 20; - №19(1). - P. 45.
5. Dreymueller D., Uhlig S., Ludwig A. ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets. // Am. J. Physiol. Lung Cell Mol. Physiol. - 2015 Feb 15; - №308(4). - P. 325- 43.
6. Eddy J.L., Schroeder J.A., Zimbler D.L., Caulfield A.J., Lathem W.W. Proteolysis of plasminogen activator inhibitor-1 by Yersinia pestis remodulates the host environment to promote virulence. // J. Thromb. Haemost. - 2016 Sep; - №14(9). - P. 1833-43.
7. El Rayes T., Catena R., Lee S., Stawowczyk M., Joshi N., Fischbach C., Powell C.A., Dannenberg A.J., Altorki N.K., Gao D., Mittal V. Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1. // Proc. Natl. Acad. Sci. U S A. - 2015 Dec 29; - №112(52). - P. 16000-5.
8. Fukui M., Takamochi K., Oh S., Matsunaga T., Suzuki K, Ando K., Suzuki K. Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias. // Ann. Thorac. Surg. - 2017 Jun; - №103(6). - P. 1781-1787.
9. Kellner H. Targeting interleukin-17 in patients with active rheumatoid arthritis: rationale and clinical potential. //Ther Adv Musculoskeletal Dis. -2013;- 5(3): - Р.141–52. DOI: http://dx.doi.org/10.1177%2F1759720X13485328.
10. Nathan C. Neutrophils and immunity: challenges and opportunities // Nat. Rev. Immunol. - 2006. – Vol. 6, №30. – P. 173-182