Subject of the article

Authors

Giyazova M.M.

Institution

Bukhara State Medical Institute

Abstract

To date, there is no branch of medicine left that would not be affected by coronavirus infection, which means that there are no organs and systems that have not been affected and have not had  pathology' from SARS-Co I -2 infection. L sually. with viral infections, as the experience of the medical society has previously shown, virologists and immunologists were engaged, but with coronavirus infection, SARS-CoV-2 penetrated so deeply and comprehensively into the body, that related experts simply could not help but touch upon the issues of studying and conducting scientific research in this direction. The study' of the process of immunobiology of the body is important in the treatment of coronavirus infection and its complications. The need for knowledge of immunobiology is also determined by the possible introduction of new medical methods and technologies in the diagnosis and treatment of viral, in particular coronavirus infection. SARS-Co\ '-2 infecting cells expressing surface receptors of angiotensin-converting enzyme-2 (ACE2) and TMPRSS2, develops active replication and release of the virus, pyroptosis occurs - damage to the molecular structure of cells, including .1 TP, nucleic acids and ASC oligomers. They are recognized by neighboring epithelial cells, endothelial cells and alveolar macrophages, causing the generation of proinflammatory' cytokines and chemokines (including IL-6, IP-10, macrophage inflammatory protein la (MI Pl a), MIPlp and MCP1). They attract monocytes, macrophages, and T cells to the site of infection, promoting further inflammation (with theattachment of IF.\f produced by T cells), a pro-inflammatory' feedback loop is created, immune cells accumulate, pro-inflammatory cytokines are produced with the development of a cytokine storm, leading to multiple organ damage. In addition, the activity of SARS-CoV-2 is enhanced through antibodydependent enhancement (ADE), which further exacerbates damage to organs, including the nervous system and oral cavity. For the treatment of symptoms and complications of coronavirus infection, it is important to take into account changes in immunity at the cellular and then at the systemic level, thereby creating conditions and certain therapy in the treatment of an infected organism and preventing the development of complications and deaths from COVID-19.

Key words

immunobiological components, clinical course of coronavirus infection, angiotensin converting enzyme, multiple organs.

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