Bulletin of fundamental and clinic medicine, 2023 №6
Subject of the article
EXPRESSION OF MELATONIN RECEPTORS TYPE 1 IN THE EPIDERMIS OF THE SKIN OF RATS UPON ADMINISTRATION OF EXOGENOUS MELATONIN ON THE BACKGROUND OF EXPERIMENTAL DESYNCHRONOSIS (120-126)
Authors
Sobolevskaya I.S. , Myadelets O.D.
Institution
Vitebsk State Medical University
Abstract
Circadian rhythms in the general integument are under the control of the local melatonin-serotonergic system. One of the main components of which is the hormone melatonin and its receptors. Chronodestruction caused by light deprivation promotes changes in the receptor part of the skin melatonin-serotonergic system. Moreover, the expression of MTNR1A receptors directly affects the effectiveness of the hormone itself. It was experimentally established that light deprivation leads to a significant decrease in the expression level of MTNR1A receptors in the epidermis on the 7th and 14th days. Administration of exogenous melatonin to animals from the first day of the experiment helps smooth out the negative effect of chronodestruction and has a beneficial effect on the epidermis.
Key words
melatonin type 1 receptors, skin, epidermis, melatonin, light deprivation.
Literature
- Slominski, A.T., Hardeland, R., Zmijewski, M.A., Slominski, R.M., Reiter, R.J., Paus, R . (2018) Melatonin: a cutaneous perspective on its production, metabolism, and functions. J Invest Dermatol, 138(3), 490–499. doi: 10.1016/j.jid.2017.10.025
- Plikus Bogi, M.V. (2018) Skin as a window to body-clock time. Proceedings of the National Academy of Sciences, 115(48),12095-12097. doi: 10.1073/pnas.1817419115
- Liu, J., Clough, S.J., Hutchinson, A.J., Adamah-Biassi, E.B., Popovska-Gorevski, M., Dubocovich, M.L. (2016) MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu Rev Pharmacol Toxicol, 56, 361– 383. doi:10.1146/annurev-pharmtox-010814-124742
- Соболевская, И.С. Особенности экспрессии рецепторов мелатонина МТ1 в кожном покрове крыс при световой депривации / И.С.Соболевская, М.И. Краснобаева, О.Д. Мяделец // Морфологiя. – 2020. - Т14, № 4. – С. 64-71
- Арзамасцев, Е.В., Гуськова, Т.А., Березовская, И.В., Любимов, Б.И., Либерман, С.С., Верстакова. О.Л. (2005) Методические указания по изучению общетоксического действия фармакологических веществ / Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / под ред. Р.У.Хабриева. – М.: Медицина, с. 41-54.
