THE SPLEEN AND ITS RESPONSE TO THE INFLUENCE OF A GENETICALLY MODIFIED PRODUCT

Bulletin of fundamental and clinic medicine, 2022 №6

Subject of the article

THE SPLEEN AND ITS RESPONSE TO THE INFLUENCE OF A GENETICALLY MODIFIED PRODUCT (165-171)

Authors

Teshaev Sh.J. , Khasanova D.A. , Teshaeva Kh.Sh.

Institution

Bukhara State Medical Institute

Abstract

In the experimental group of laboratory animals, visible changes in the spleen are noted, characterized by an increase in size, average weight, changes in the structure and color of the organ under study. A high synchronicity of quantitative changes in the central and peripheral part of the lymphoid nodule and the red pulp of the spleen under the conditions of GMO use was revealed. It is characterized by inter-organ linear correlation relationships between the same and dissimilar types of cells and in some cases even corresponds to the values within the organs. A genetically modified product-soy flour negatively affects the condition of the spleen.

Key words

genetically modified product, experimental animals, spleen, morphology.

Literature

  1. Ащеулов А.Д. Влияние ГМО на здоровье человека // «Диалог культур». Сборник материалов 2 Всероссийского заочного конкурса НИР. - Стерлитаменск, Башкирия, Россия. - 2015. - С.12-15.
  2. Жармухамедова Т.Ю., Семушина С.Г., Пахомова И.А., Пименов М.С., Мурашов А.Н. Международные правила работы с лабораторными животными при проведении доклинических испытаний // Токсикологический вестник. - 2011. - №4(109). - С.2-9.
  3. Каркищенко Н.Н., Грачева С.В. Руководство по лабораторным животным и альтернативным моделям в биомедицинских исследованиях. Москва: «Профиль», 2010. - 241 c.
  4. Коробчанский, В.А., Герасименко, О.И., Иваненко, Т.А. Проблемы медико-биологической безопасности регулярного употребления в пищу пищевой продукции содержащей ГМО // Проблеми харчування. - Харьков, 2010. - №3-4. - С.38-43.
  5. Кузнецов В.В., Куликов, А.М. Генетически модифицированные риски и полученные из них продукты: реальные и потенциальные риски // Российский химический журнал РХО им. Менделеева. - Москва, 2005. - №69 (4). - С.70-83.
  6. Khasanova D.A., Teshaev Sh.J. Topografic-anatomical features of lymphoid structures of the small intestine of rats in norm and against the background of chronic radiation diseases- European science review № 9-10 2018, P. 197-198
  7. Khasanova D.A. Current problems of safety of genetically modified foods (literature review), 2020; 5 (45): 20-27
  8. Khasanova D.A., Teshaev SJ. Effects of genetically modified products on the human body (literature review), 2020; 5(45): 5-19
  9. Khasanova D.A. Wirkung eines gen-modifizierten produkts auf die morphologischen parameter der strukturen der milz weißer ratten Scientific collection “Interconf” Science and practice: implementation to modern society Great Britain. 2020; PP. 1258-1261
  10. Kim SH, Kim HM, Ye YM, Nahm DH, Park HS, Ryu SR, Lee BO. Evaluating the allergic risk of genetically modified soybean . Yenisei Med. J. 2006;47:505-512.
  11. Korobchansky VA, Gerasimenko OI, Ivanenko TA. Problems of medical and biological safety of regular consumption of food products containing GMOs.Problemiharchuva. 2010; 3(4): 38-43.
  12. Krishan Kumar, GeetikaGambhir, Abhishek Dass, Amit Kumar Tripathi, Alla Singh, Abhishek Kumar Jha, Pranjal Yadava, Mukesh Choudhary&Sujay Rakshit/ Genetically modified crops: current status and future prospects//Planta volume 251, Article number: 91 (2020)
  13. McCann MC, Liu K, Trujillo WA, Dogbert RC. Glyphosatetolerant soybeans remain compositionally equivalent toconventionalsoybeans (Glycinemax L) during three year so field-testing. J. Agriculture and Food Chem. 2005;53:5331-5335.
  14. Poznyakovsky VM. Genetically modified food sources: relevance of the problem, technology of creation, safety and control issues. Techn. Tech. of Food Prod. 2009
  15. Tyshko NV. Control over genetically-modified sources of plant origin in food: scientific basis and methodical maintenance. Nutrition issues [Problems of Nutrition]. 2017; 86 (5): 29-33.
  16. Zhengyan Feng, Yanfei Mao, NanfeiXu, Botao Zhang, Pengliang Wei, Dong-Lei Yang, Zhen Wang, Zhengjing Zhang, RuiZheng, Lan Yang, Liang Zeng, Xiaodong Liu, and Jian-Kang Zhu/ Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis//PNAS March 25, 2014 111 (12) 4632- 463

ARTICLES