Bulletin of fundamental and clinic medicine, 2022 №6
Subject of the article
PATHOMORPHOLOGICAL CHANGES IN THE TESTES IN TRAUMATIC BRAIN INJURY (39-44)
Authors
Rakhimova Gulnoz Shamsiyevna
Institution
Bukhara State Medical Institute
Abstract
This article presents the results of a scientific study conducted under conditions of simulated brain injury. 150 white mongrel rats at the age of three months received a traumatic brain injury in the “traffic accident and catatrauma" model. In the acute phase, rat testicles were isolated and morphometric and morphofunctional aspects were studied. The results showed that pathomorphological changes were clearly manifested in all tissues of the testes, including the seminal tubules, stroma, endocrine structures, epithelial-spermatogenic layer, and these indicators varied depending on the day after the injury.
Key words
morphometry, testes, modeling, traumatic brain injury, epithelial-spermatogenic layer.
Literature
- Gao Y, Mruk DD, Cheng CY. Sertoli cells are the target of environmental toxicants in the testis - a mechanistic and therapeutic insight. Expert Opin Ther Targets. 2015;19(8):1073-90. doi: 10.1517/14728222.2015.1039513. Epub 2015 Apr 26.
- Barber TM, Kyrou I, Kaltsas G, Grossman AB, Randeva HS, Weickert MO. Mechanisms of Central Hypogonadism. Int J Mol Sci. 2021 Jul 30;22(15):8217.
- Sansone A, Di Dato C, de Angelis C, Menafra D, Pozza C, Pivonello R, Isidori A, Gianfrilli D. Smoke, alcohol and drug addiction and male fertility. Reprod Biol Endocrinol. 2018 Jan 15;16(1):3.
- García-Díaz EC, Gómez-Quiroz LE, Arenas-Ríos E, AragónMartínez A, Ibarra-Arias JA, del Socorro I Retana-Márquez M. Oxidative status in testis and epididymal sperm parameters after acute and chronic stress by cold-water immersion in the adult rat. Syst Biol Reprod Med. 2015;61(3):150-160.
- Машарипов А.С., Искандаров А.И. Экспертная оценка давности черепно-мозговой травмы по морфологическим изменениям внутренних органов. Сибирский медицинский журнал, 2010, № 2. - С.51-52.
- Федотов А.В., Астраханцев А. Ф. Морфологические изменения мужских половых желез при черепно-мозговой травме // Судебно-медицинская экспертиза, 2017, №2. – С.18-20.
- Shamsievna R. G. Secondary Tissue Damage in Acute Traumatic Brain Injury //Web of Synergy: International Interdisciplinary Research Journal. – 2023. – Т. 2. – №. 5. – С. 469-473.
- Ribeiro CT, De Souza DB, Costa WS, Sampaio FJB, PereiraSampaio MA. Immediate and late effects of chronic stress in the testes of prepubertal and adult rats. Asian J Androl. 2018 Jul-Aug;20(4):385-390
- G. Sh., R. (2023). Morphometric Studies of the Testes of White Mongrel Rats in the Acute Stage of Traumatic Brain Injury. International Journal of Integrative and Modern Medicine, 1(2), 57–60.
- Hou G, Xiong W, Wang M, Chen X, Yuan TF. Chronic stress influences sexual motivation and causes damage to testicular cells in male rats. J Sex Med. 2014;11(3):653-663.