THE ROLE OF APOPTOSIS MARKERS AND ANGIOGENESIS REGULATORS IN THE PATHOGENESIS OF GENITAL ENDOMETRIOSIS

Bulletin of fundamental and clinic medicine, 2022 №6

Subject of the article

THE ROLE OF APOPTOSIS MARKERS AND ANGIOGENESIS REGULATORS IN THE PATHOGENESIS OF GENITAL ENDOMETRIOSIS (199-206)

Authors

Umidova N.N.

Institution

Bukhara State Medical Institute. assistant department of histology,cytology,embryology.

Abstract

Endometriosis is one of the most common gynecological diseases, which reflects the medical and social significance of the problem of effective diagnosis and treatment. To date, the causes, diagnosis and treatment of this disease remain the subject of controversy. The pathogenesis of the disease is multifactorial and has not been studied enough, non-invasive examination methods have a relative diagnostic value, so modern therapeutic approaches often do not provide a complete cure.

Key words

endometriosis, diagnostics, proteins, genes, mikro RNK

Literature

  1. Al-Jefout Moamar, Artymuk N. Should we consider asymptomatic and microscopic endometriosis as a disease? Fundamental and clinical medicine. 2016;1(2):83-87. [Эл-Джефут М., Артымук Н.В. Соответствует ли скрытый (бессимптомный или микроскопический) эндометри-оз определению болезни? Fundamental'naya i klinisheskaya meditsina. 2016;1(2):83-87. (In Russ.).]
  2. Endometriosis: pathogenesis and treatment. Harada T, eds. Springer, Japan; 2014. DOI: 10,1007 / 978-4-431-54421-0
  3. Knapp VJ. How old is endometriosis? Late 17th- and 18th-century European descriptions of the disease. Fertil Steril. 1999;72(1):10-14. DOI: 10.1016/s0015-0282(99)00196-x
  4. Sampson JA. Metastatic or embolic endometriosis due to menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol._1927;3(2): 93-110.
  5. Sampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14(2):422-469.
  6. Rokitansky C. Über Uterusdrüsen-Neubildung in Uterus-und Ovarial-Sarcomen. (On the neoplasm of uterus glands on uterine and ovarian sarcomas). Z Ges Aerzte Wien. 1860;16:577-581.
  7. Intellectual Development of Carl Von Rokitansky. A History of Endometriosis. Springer, London; 2011. DOI: https://doi. org/10.1007/978-0- 85729-585-9_2
  8. Cullen TS. Adenomyoma of the uterus. Philadelphia, WB: Saunders; 1908.
  9. Cullen TS. Adenomyoma of the rectovaginal septum. JAMA. 1914;62(11): 835-839.
  10. Ja S. Perforating hemorrhagic (chocolate) cysts of the ovary; Their importance and specially their relation to pelvic adenomas of the endometrorial type. Arch Surg. 1921;3: 245323.

ARTICLES